CD40 Antigens D019013

Related MeSH Hierarchy (4)

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Immune Checkpoint Proteins » CD40 Antigens

Chemicals and Drugs [D] » Biological Factors [D23] » Biomarkers » Antigens, Differentiation » Antigens, Differentiation, B-Lymphocyte » CD40 Antigens

Description

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.   MeSH

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