Genes, erbB D018815

Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Structures » Genome » Genome Components » Genes » Genes, Neoplasm » Oncogenes » Proto-Oncogenes » Genes, erbB

Description

Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.   MeSH

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Subtype Terms (2)

Genes, erbB-1
3 approved drugs

Genes, erbB-2
29 drugs (19 approved, 10 experimental)

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