Polyendocrinopathies, Autoimmune D016884

Diseases [C] » Endocrine System Diseases [C19] » Polyendocrinopathies, Autoimmune

Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Polyendocrinopathies, Autoimmune

Description

Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.   MeSH

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