Lupus Coagulation Inhibitor D016682

Related MeSH Hierarchy (4)

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Blood Proteins » Immunoproteins » Immunoglobulins » Antibodies » Autoantibodies » Antibodies, Antiphospholipid » Lupus Coagulation Inhibitor

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Blood Proteins » Serum Globulins » Immunoglobulins » Antibodies » Autoantibodies » Antibodies, Antiphospholipid » Lupus Coagulation Inhibitor

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Globulins » Serum Globulins » Immunoglobulins » Antibodies » Autoantibodies » Antibodies, Antiphospholipid » Lupus Coagulation Inhibitor

Chemicals and Drugs [D] » Biological Factors [D23] » Blood Coagulation Factor Inhibitors » Lupus Coagulation Inhibitor

Description

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.   MeSH

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