Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Motor Neuron Disease
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Motor Neuron Disease
Description
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) MeSH
Hierarchy View
Subtype Terms (3)
Amyotrophic Lateral Sclerosis
216 drugs (96 approved, 120 experimental)
Bulbar Palsy, Progressive
1 experimental drug
Muscular Atrophy, Spinal
28 drugs (18 approved, 10 experimental)
Phase 4 Indicated Drugs (1)
Phase 3 Indicated Drugs (1)
Organization Involved with Phase 4 Indications (3)
Organization Involved with Phase 3 Indications (74)
California Institute for Regenerative Medicine
California Pacific Medical Center Research Institute
Carolinas MDA Neuromuscular/ALS Center-Carolinas Medical System
Katholieke Universiteit Leuven
Laboratoire français de Fractionnement et de Biotechnologies
National Institute of Neurological Disorders and Stroke (NINDS)
Princess Beatrix Muscle Foundation
State University of New York, Syracuse
Universidad Autonoma de Nuevo Leon
Organization Involved with Phase 2 Indications (145)
ALS Therapy Development Institute
Andalusian Initiative for Advanced Therapies
Andalusian Initiative in Advanced Therapies
Bennett, James P., Jr., M.D., Ph.D.
Brain Chemistry Labs, Institute for EthnoMedicine
Catholic University of Sacred Heart, Rome
Center for Neurologic Study, La Jolla, California,
Centre Hospitalier Universitaire de Nīmes
El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Forbes Norris MDA/ALS Research Center
Fundación Universidad Católica de Valencia San Vicente Mártir
Genervon Biopharmaceuticals, LLC
Hoosier Cancer Research Network
IRCCS National Neurological Institute C. Mondino Foundation
Isfahan neurosciences research center
Muscular Dystrophy Association
National Center for Complementary and Integrative Health (NCCIH)
National Center for Research Resources (NCRR)
Neuraltus Pharmaceuticals, Inc.
Neurogen Brain and Spine Institute
Office of Dietary Supplements (ODS)
Phil Smith Neuroscience Institute at Holy Cross Hospital
Phoenix Neurological Associates, LTD
Polski Bank Komorek Macierzystych JSC (PBKM)
Royal Brisbane & Women's Hospital
South Shore Neurologic Associates
Universidad Católica de Valencia
University Hospital Motol, Prague, Czech Republilc
University of California, San Francisco
University of Campania Luigi Vanvitelli
University of Eastern Piedmont
University of Modena and Reggio Emilia
University of Naples Frederico II
University of Texas at Houston
Organization Involved with Other Experimental Indications (15)
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UMLS Data
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