Lambert-Eaton Myasthenic Syndrome D015624

Related MeSH Hierarchy (6)

Diseases [C] » Neoplasms [C04] » Neoplasms by Site » Nervous System Neoplasms » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Diseases [C] » Neoplasms [C04] » Paraneoplastic Syndromes » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Neuromuscular Junction Diseases » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Diseases [C] » Nervous System Diseases [C10] » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome

Description

An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)   MeSH

Approved Indicated Drugs (2)


Organization Involved with Phase 3 Indications (3)

Organization Involved with Phase 1 Indications (1)

Hierarchy Tree View

UMLS Data


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