Diseases [C] » Neoplasms [C04] » Neoplasms by Histologic Type » Leukemia » Leukemia, Myeloid » Leukemia, Myeloid, Acute
Description
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. MeSH
Hierarchy View
Subtype Terms (7)
Leukemia, Eosinophilic, Acute
56 drugs (41 approved, 15 experimental)
Leukemia, Erythroblastic, Acute
7 drugs (6 approved, 1 experimental)
Leukemia, Mast-Cell
23 drugs (16 approved, 7 experimental)
Leukemia, Megakaryoblastic, Acute
18 drugs (12 approved, 6 experimental)
Leukemia, Monocytic, Acute
72 drugs (49 approved, 23 experimental)
Leukemia, Promyelocytic, Acute
24 drugs (17 approved, 7 experimental)
Approved Indicated Drugs (14)
Phase 3 Indicated Drugs (99)
allogeneic bone marrow derived mesenchymal stem cell
allogeneic hematopoietic stem cells (Hemacord)
Anti-thymocyte Globulin (Rabbit) (Thymoglobulin)
autologous bone marrow derived mesenchymal cells
hla-matched related donor bone marrow
hla-mismatched donor peripheral stem cell infusion
hsvtk retrovirally-transduced donor t lymphocytes
Phase 2 Indicated Drugs (293)
allogeneic adipose derived mesenchymal stem cell
allogeneic natural killer cells
anti-minor histocompatibility complex (miha) donor t-lymphocytes
autologous dendritic cells electroporated with wt1 mrna
autologous hematopoietic stem cells
autologous mesenchymal stem cells
autologous natural killer cells
bone marrow derived mesenchymal stem cells
brentuximab vedotin (adcetris)
car.70/il15-transduced cb-nk cells
cd3,cd19 depleted hematopoietic stem cells
cd3-cd56+ natural killer cells
cord blood hematopoietic stem cell
cytokine induced memory-like nk cells
donor il-15 stimulated nk cells infusion
donor tcr alpha/beta-depleted cells
donor t-lymphocytes depleted ex vivo of host alloreactive t-cells
gvax pancreatic cancer vaccine
haplo-identical hematopoietic stem cells
haploidentical mononuclear cells
haploidentical transplantation of t-cell depleted graft
multi-peptide cmv-modified vaccinia ankara vaccine
Phase 1 Indicated Drugs (299)
90Yttrium-labelled Anti-CD66 Monoclonal Antibody
allogeneic cd123car-cd28-cd3zeta-egfrt-expressing t-lymphocytes
allogeneic double negative t cells
allogeneic gamma-delta t cells
antigen-loaded cultured dendritic cells
anti-ley-scfv-cd28-zeta vector
autologous anti-cd 123 car tcr/4-1bb-expressing t-lymphocytes
autologous cd123car-cd28-cd3zeta-egfrt-expressing t lymphocytes
cd123car-41bb-cd3zeta-egfrt-expressing t cells
cd25-depleted peripheral blood mononuclear cell
cd8+ and cd4+ donor memory t-cells-expressing ha1-specific tcr
chimeric antigen receptor t cells, eps8 or wt1 peptide specific dendritic cell
dec-205/ny-eso-1 fusion protein cdx-1401
donor-derived wt1-ctl and p-ctl
ex vivo cd3/cd28 costimulated umbilical cord blood t cells
hyaluronidase (human recombinant) (hylenex)
in111 anti-cd45 monoclonal antibody bc8
interferon gamma (ifnγ)-primed human bone marrow-derived mesenchymal stromal cells
in vitro-treated peripheral blood stem cell
Other Experimental Indicated Drugs (17)
Organization Involved with Phase 4 Indications (23)
Organization Involved with Phase 3 Indications (182)
Albert Einstein Israelite Hospital
All India Institute of Medical Sciences
Blood and Marrow Transplant Clinical Trials Network
Cancer and Leukemia Group B (CALGB)
Center for International Blood and Marrow Transplant Research
Changzhou No.2 People's Hospital
Chinese Academy of Medical Sciences
CHU Haut-Leveque Pessac 33604 France
Cohen Children's Medical Center of New York
Cyclacel Pharmaceuticals, Inc.
Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG)
Dutch Childhood Oncology Group
European Organisation for Research and Treatment of Cancer
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
French Innovative Leukemia Organisation
German Federal Ministry of Education and Research
Gottfried Wilhelm Leibniz Universität Hannover
Gruppo Italiano Malattie EMatologiche dell'Adulto
Gruppo Italiano Trapianto di Midollo Osseo
Hannover Clinical Trial Center GmbH
HOVON - Dutch Haemato-Oncology Association
National Cancer Institute, France
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
People's Liberation Army of China
Physicians, Innovations, Science for Children Fund
Shandong Province Qianfoshan Hospital
Shengli Oilfield Central Hospital
State University of New York, Buffalo
The Christie NHS Foundation Trust
The First People's Hospital of Lianyungang
Organization Involved with Phase 2 Indications (309)
Associazione Italiana per la Ricerca sul Cancro
Bambino Gesù Hospital and Research Institute
Bio-Cancer Treatment International Limited
BioMed Valley Discoveries, Inc
Case Western Reserve University
Chao Family Comprehensive Cancer Center
Children's Hospital Los Angeles
Children's National Medical Center
Chongqing Precision Biotech Co., Ltd
City of Hope National Medical Center
Colorado Blood Cancer Institute
Department of Health and Human Services
Department of Health, United Kingdom
Doris Duke Charitable Foundation
Federal University of Rio Grande do Sul
Froedtert Memorial Lutheran Hospital
Good Samaritan Hospital, Cincinnati
Groupe Francophone des Myelodysplasies
Grupo Cooperativo de Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias
Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Hospital San Pedro de Alcantara
Innovative Therapies For Children with Cancer Consortium
Innovent Biologics (Suzhou) Co. Ltd.
Istituto Nazionale per lo Studio e la Cura dei Tumori
Katholieke Universiteit Leuven
Korea Research Institute of Bioscience and Biotechnology
Medical University of South Carolina
Memorial Sloan-Kettering Cancer Center
Moorgreen Hospital, Southampton
National Institutes of Health (NIH)
North Shore Hospital, New Zealand
Oregon Health and Science University
Pavlov First Saint Petersburg State Medical University
Pediatric Brain Tumor Consortium
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Rocky Mountain Cancer Centers - Denver Midtown
Royal Marsden Hospital NHS Trust
Shanghai institute of Hematology
Shanghai Ruijin Hospital North
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd
Shenzhen Geno-Immune Medical Institute
Shijiazhuang Pharma Group (CSPC)
Suzhou Yasheng Pharmaceutical Co., Ltd
Technical University of Munich
The First People's Hospital of Yunan Province
The Foundation Institute San Raffaele G. Giglio of Cefalù
The Korean Society of Hematology
The Korean Society of Pediatric Hematology Oncology
The University of Texas, Dallas
Tokyo Metropolitan Komagome Hospital
Universidad Autonoma de Madrid
Universita' Cattolica del Sacro Cuore
Université catholique de Louvain
University Hospital of Mont-Godinne
University of Alabama, Birmingham
University of California, Davis
University of California, Irvine
University of California, Los Angeles
University of California, San Diego
University of California, San Francisco
University of Colorado, Denver
University of Medicine and Dentistry of New Jersey
University of North Carolina at Chapel Hill
University of Southern California
Virginia Commonwealth University
Vita-Salute University of Milano. Italy
Organization Involved with Phase 1 Indications (132)
Alex's Lemonade Stand Foundation
American Society for Blood and Marrow Transplantation
Applied Physiology Research Center
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology
Big Ten Cancer Research Consortium
China Academy of Chinese Medical Sciences
Damon Runyon Cancer Research Foundation
GCP-Service International Ltd. & Co. KG
Georgia Institute of Technology
Hamilton Health Sciences Corporation
Hebei Senlang Biotechnology Inc., Ltd.
High Impact Clinical Research Support Program
Huazhong University of Science and Technology
Icahn School of Medicine at Mount Sinai
Innovative Clinical Research, Inc.
Institut de Recherche Clinique sur les Cancers et le Sang
Seyyed-alshohada hospital of Isfahan
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China
South Plains Oncology Consortium
Sunshine Lake Pharma Co., Ltd.
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Technical University of Denmark
Translational Drug Development
University of British Columbia
University of Illinois at Chicago
University of Maryland, College Park
University of Rome Tor Vergata
University of Science and Technology of China
William Lawrence and Blanche Hughes Foundation
Organization Involved with Other Experimental Indications (13)
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UMLS Data
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