Related MeSH Hierarchy (5)
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Peripheral Nervous System Diseases » Polyneuropathies » Hereditary Sensory and Motor Neuropathy » Spastic Paraplegia, Hereditary
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Congenital Abnormalities » Nervous System Malformations » Hereditary Sensory and Motor Neuropathy » Spastic Paraplegia, Hereditary
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Heredodegenerative Disorders, Nervous System » Hereditary Sensory and Motor Neuropathy » Spastic Paraplegia, Hereditary
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Heredodegenerative Disorders, Nervous System » Hereditary Sensory and Motor Neuropathy » Spastic Paraplegia, Hereditary
Diseases [C] » Nervous System Diseases [C10] » Nervous System Malformations » Hereditary Sensory and Motor Neuropathy » Spastic Paraplegia, Hereditary
Description
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) MeSH
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Phase 2 Indicated Drugs (3)
Organization Involved with Phase 2 Indications (3)
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