Chemicals and Drugs [D] » Organic Chemicals [D02] » Carboxylic Acids » Acids, Carbocyclic » Phthalic Acids » Phthalimides » Thalidomide
Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, 1-Ring » Piperidines » Piperidones » Thalidomide
Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, Fused-Ring » Heterocyclic Compounds, 2-Ring » Isoindoles » Phthalimides » Thalidomide
Description
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. MeSH
Hierarchy View
Phase 3 Indicated Drugs (6)
Phase 2 Indicated Drugs (1)
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