Neoplastic Syndromes, Hereditary D009386

Diseases [C] » Neoplasms [C04] » Neoplastic Syndromes, Hereditary

Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Neoplastic Syndromes, Hereditary

Description

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.   MeSH

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Subtype Terms (14)

Adenomatous Polyposis Coli
31 drugs (16 approved, 15 experimental)

Basal Cell Nevus Syndrome
17 drugs (13 approved, 4 experimental)

Birt-Hogg-Dube Syndrome
2 approved drugs

Colorectal Neoplasms, Hereditary Nonpolyposis
20 drugs (16 approved, 4 experimental)

Dysplastic Nevus Syndrome
1 experimental drug

Exostoses, Multiple Hereditary
1 experimental drug

Hamartoma Syndrome, Multiple
6 drugs (4 approved, 2 experimental)

Hereditary Breast and Ovarian Cancer Syndrome
5 drugs (3 approved, 2 experimental)

Li-Fraumeni Syndrome
1 approved drug

Multiple Endocrine Neoplasia
4 drugs (3 approved, 1 experimental)

Neurofibromatoses
16 drugs (14 approved, 2 experimental)

Peutz-Jeghers Syndrome
3 approved drugs

Tuberous Sclerosis
13 drugs (10 approved, 3 experimental)

Wilms Tumor
82 drugs (49 approved, 33 experimental)


Phase 1 Indicated Drugs (2)


Organization Involved with Phase 2 Indications (1)

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UMLS Data


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