Related MeSH Hierarchy (4)
Diseases [C] » Hemic and Lymphatic Diseases [C15] » Hematologic Diseases » Leukocyte Disorders » Phagocyte Bactericidal Dysfunction » Granulomatous Disease, Chronic
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Genetic Diseases, X-Linked » Granulomatous Disease, Chronic
Diseases [C] » Immune System Diseases [C20] » Immunologic Deficiency Syndromes » Phagocyte Bactericidal Dysfunction » Granulomatous Disease, Chronic
Diseases [C] » Pathological Conditions, Signs and Symptoms [C23] » Pathologic Processes » Disease Attributes » Chronic Disease » Granulomatous Disease, Chronic
Description
A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern. MeSH
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Approved Indicated Drugs (1)
Phase 4 Indicated Drugs (1)
Phase 3 Indicated Drugs (2)
Phase 1 Indicated Drugs (1)
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (1)
Organization Involved with Phase 2 Indications (27)
Blood and Marrow Transplant Clinical Trials Network
California Institute for Regenerative Medicine
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Organization Involved with Phase 1 Indications (3)
Organization Involved with Other Experimental Indications (3)
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UMLS Data
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