Related MeSH Hierarchy (5)
Diseases [C] » Nervous System Diseases [C10] » Nervous System Malformations » Hereditary Sensory and Motor Neuropathy » Charcot-Marie-Tooth Disease
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Peripheral Nervous System Diseases » Polyneuropathies » Hereditary Sensory and Motor Neuropathy » Charcot-Marie-Tooth Disease
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Congenital Abnormalities » Nervous System Malformations » Hereditary Sensory and Motor Neuropathy » Charcot-Marie-Tooth Disease
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Heredodegenerative Disorders, Nervous System » Hereditary Sensory and Motor Neuropathy » Charcot-Marie-Tooth Disease
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Heredodegenerative Disorders, Nervous System » Hereditary Sensory and Motor Neuropathy » Charcot-Marie-Tooth Disease
Description
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343) MeSH
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Phase 3 Indicated Drugs (7)
Phase 2 Indicated Drugs (7)
Organization Involved with Phase 4 Indications (2)
Organization Involved with Phase 3 Indications (17)
Organization Involved with Phase 2 Indications (10)
Organization Involved with Other Experimental Indications (1)
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