Related MeSH Hierarchy (16)
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Brain Diseases, Metabolic » Brain Diseases, Metabolic, Inborn » Adrenoleukodystrophy
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Brain Diseases, Metabolic » Brain Diseases, Metabolic, Inborn » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Leukoencephalopathies » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Nervous System Diseases [C10] » Demyelinating Diseases » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Nervous System Diseases [C10] » Neurologic Manifestations » Neurobehavioral Manifestations » Intellectual Disability » Mental Retardation, X-Linked » Adrenoleukodystrophy
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Genetic Diseases, X-Linked » Mental Retardation, X-Linked » Adrenoleukodystrophy
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Heredodegenerative Disorders, Nervous System » Mental Retardation, X-Linked » Adrenoleukodystrophy
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Metabolism, Inborn Errors » Brain Diseases, Metabolic, Inborn » Adrenoleukodystrophy
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Metabolism, Inborn Errors » Brain Diseases, Metabolic, Inborn » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Metabolism, Inborn Errors » Peroxisomal Disorders » Adrenoleukodystrophy
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Brain Diseases, Metabolic » Brain Diseases, Metabolic, Inborn » Adrenoleukodystrophy
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Brain Diseases, Metabolic » Brain Diseases, Metabolic, Inborn » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Metabolism, Inborn Errors » Brain Diseases, Metabolic, Inborn » Adrenoleukodystrophy
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Metabolism, Inborn Errors » Brain Diseases, Metabolic, Inborn » Hereditary Central Nervous System Demyelinating Diseases » Adrenoleukodystrophy
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Metabolism, Inborn Errors » Peroxisomal Disorders » Adrenoleukodystrophy
Diseases [C] » Endocrine System Diseases [C19] » Adrenal Gland Diseases » Adrenal Insufficiency » Adrenoleukodystrophy
Description
An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS). MeSH
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Approved Indicated Drugs (3)
Phase 4 Indicated Drugs (1)
Phase 3 Indicated Drugs (1)
Phase 1 Indicated Drugs (2)
Other Experimental Indicated Drugs (6)
Organization Involved with Phase 3 Indications (13)
Organization Involved with Phase 2 Indications (15)
Organization Involved with Phase 1 Indications (3)
Organization Involved with Other Experimental Indications (2)
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UMLS Data
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