Tripeptidyl-Peptidase 1 D000091346

Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Exopeptidases » Aminopeptidases » Tripeptidyl-Peptidase 1

Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Exopeptidases » Dipeptidyl-Peptidases and Tripeptidyl-Peptidases » Tripeptidyl-Peptidase 1

Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Serine Proteases » Tripeptidyl-Peptidase 1

Description

Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVECEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.   MeSH

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