Mast Cell Activation Disorders D000090362

Diseases [C] » Immune System Diseases [C20] » Mast Cell Activation Disorders

Description

A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress.   MeSH

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Subtype Terms (2)

Mastocytosis
21 drugs (13 approved, 8 experimental)


Phase 2 Indicated Drugs (2)

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