Discoidin Domain Receptors D000070818

Related MeSH Hierarchy (5)

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptor Protein-Tyrosine Kinases » Discoidin Domain Receptors

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Collagen » Discoidin Domain Receptors

Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Immunologic » Receptors, Mitogen » Discoidin Domain Receptors

Description

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.   MeSH

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