sucralose Report issue

Small molecule Experimental
AACT ChEMBL MeSH PubChem

Active Ingredient History

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Sucralose is an artificial sweetener and sugar substitute. The majority of ingested sucralose is not broken down by the body, so it is noncaloric. In the European Union, it is also known under the E number E955. It is produced by chlorination of sucrose, selectively replacing three of the hydroxy groups in the C1, C4, and C6 positions to give a 1,6-dichloro-1,6-dideoxyfructose–4-chloro-4-deoxygalactose disaccharide. Sucralose is about 320 to 1,000 times sweeter than sucrose, three times as sweet as both aspartame and acesulfame potassium, and twice as sweet as sodium saccharin. Evidence of benefit is lacking for long-term weight loss, with some data supporting weight gain and heart disease risks.   Wikipedia

Chemistry

  • SMILES: OC[C@@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H](O)[C@H]1Cl
  • InChIKey: BAQAVOSOZGMPRM-KBFHZYTNSA-N
  • Mol. Mass: 397.64
  • ALogP: -1.66
  • ChEMBL Molecule:
    sucralose  
More Chemistry

Pharmacology

Alternative names

1',4',6'-trichloro-1',4,6'-trideoxygalactosucrose | 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl-4-chloro-4-deoxy-alpha-d-galactopyranoside | alpha-d-galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl 4-chloro-4-deoxy- | splenda | sucralose | trichlorogalactosucrose | trichlorogalacto-sucrose | trichlorosucrose

Organizations (29)

Research & Development (29)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (6)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (6)


 

Body Weight Changes (Phase 2)

Burns (Phase 1)

Colonic Neoplasms (Phase 3)

Diabetes Mellitus, Type 2 (Phase 3)

Healthy Volunteers (Phase 2)

Overweight (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 21
  • # of Trial Organizations: 29

Trials by Phase

Trial Phase Start Date Organizations Indications

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