Active Ingredient History

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Betahistine is an orally administered, centrally acting histamine H1 receptor agonist with partial H3 antagonistic activity. It is proposed that betahistine may reduce peripherally the asymmetric functioning of the sensory vestibular organs in addition to increasing vestibulocochlear blood flow by antagonising local H3 heteroreceptors. Betahistine acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibular nuclei through antagonism of H3 autoreceptors. This mechanism, together with less specific effects of betahistine on alertness regulation through cerebral H1 receptors, should promote and facilitate central vestibular compensation. Betahistine is used to treat the symptoms associated with Ménière's disease, a condition of the inner ear which causes, vertigo (dizziness), tinnitus (ringing in the ears), hearing loss.   NCATS

More Chemistry
2-[2-(methylamino)ethyl]pyridine | [2-(2-pyridyl)ethyl]methylamine | 2-(beta-methylaminoethyl)pyridine | betahistina | betahistine | beta-histine | betahistine dihydrobromide | betahistine dihydrochloride | betahistine hcl | betahistine hydrochloride | betahistine mesilate | betahistine mesylate | betahistine methanesulfonate | betahistinum | merislon | n-methyl-2-(2-pyridinyl)ethanamine | n-methyl-2-pyridineethanamine | pt-9 | serc | serc-16 | serc-8 | verum


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