Active Ingredient History

  • Now
Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine. Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Argatroban is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. At therapeutic concentrations, Argatroban has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein). Argatroban is capable of inhibiting the action of both free and clot-associated thrombin. Argatroban is indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. Argatroban is indicated as an anticoagulant in patients with or at risk for heparin-induced thrombocytopenia undergoing percutaneous coronary intervention (PCI).   NCATS

  • SMILES: C[C@@H]1CCN([C@H](C1)C(O)=O)C(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)C2=CC=CC3=C2NCC(C)C3
  • Mol. Mass: 508.634
  • ALogP: 0.91
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$58.3933 - $430.7933
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl- | 4-methyl-1-(n(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-l-arginyl)-2-piperidinecarboxylic acid | acova | argatroban | argatroban hydrate | argatroban in sodium chloride | argatroban monohydrate | argatroban sodium | dk-7419 | gn1600 | gn-1600 | mci 9038 | mci-9038 | md805 | md 805 | md-805 | mmtqap | mpqa | novastan


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