Active Ingredient History
Ondansetron (ZOFRAN®) is a selective 5-HT3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by radiotherapy, anesthesia, surgery or cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. It is not certain whether ondansetron's antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. The released serotonin may stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Abdominal Pain (Phase 4)
Alcoholism (Phase 4)
alpha 1-Antitrypsin Deficiency (Phase 1)
Amphetamine-Related Disorders (Phase 2)
Analgesia (Phase 3)
Analgesics (Phase 4)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anesthesia, Epidural (Phase 3)
Anesthesia, General (Phase 3)
Anesthesia, Spinal (Phase 4)
Antiemetics (Phase 4)
Antineoplastic Agents (Phase 2/Phase 3)
Arthralgia (Phase 3)
Bariatric Surgery (Phase 3)
Behavior (Phase 4)
Bile Duct Neoplasms (Phase 2)
Bipolar Disorder (Phase 4)
Body Temperature Changes (Phase 4)
Brain Concussion (Phase 1)
Brain Diseases (Phase 1)
Brain Injuries, Traumatic (Phase 1)
Brain Neoplasms (Phase 2)
Breast Diseases (Phase 3)
Breast Neoplasms (Phase 4)
Burkitt Lymphoma (Phase 2)
Caffeine (Phase 3)
Cannabis (Phase 4)
Cardiac Output (Phase 2)
Cardiac Output, Low (Phase 4)
Cervical Intraepithelial Neoplasia (Phase 2)
Cesarean Section (Phase 4)
Chills (Phase 4)
Chlorzoxazone (Phase 4)
Cholangiocarcinoma (Phase 2)
Cholecystectomy, Laparoscopic (Phase 4)
Cholecystitis (Phase 2)
Cholelithiasis (Phase 4)
Chronic Pain (Phase 4)
Cocaine-Related Disorders (Phase 4)
Cognition Disorders (Phase 4)
Colorectal Surgery (Phase 3)
Constipation (Phase 4)
Dehydration (Phase 4)
Depression (Phase 2)
Dexmedetomidine (Phase 3)
Diabetes Mellitus (Phase 2)
Diagnosis, Dual (Psychiatry) (Phase 4)
Diarrhea (Phase 4)
Drug Administration Schedule (Phase 2)
Drug Interactions (Phase 3)
Drug Overdose (Phase 4)
Dyspepsia (Phase 2)
Dyspnea (Early Phase 1)
Emergence Delirium (Phase 1)
Endoscopy (Phase 4)
Fasting (Phase 1)
Fractures, Bone (Phase 4)
Gabapentin (Phase 3)
Gallbladder Neoplasms (Phase 2)
Gallstones (Phase 4)
Gastritis (Phase 3)
Gastroenteritis (Phase 4)
General Surgery (Phase 3)
Genital Neoplasms, Female (Phase 3)
Glioma (Phase 2)
Headache (Phase 4)
Healthy Volunteers (Phase 3)
Heart (Phase 4)
Heart Diseases (Phase 4)
Hematologic Diseases (Phase 2)
Hemodynamics (Phase 4)
Hernia, Inguinal (Phase 4)
HIV Infections (Phase 4)
Hodgkin Disease (Phase 2)
Hyperemesis Gravidarum (Phase 2)
Hypotension (Phase 4)
Infections (Phase 3)
Intestinal Diseases (Phase 4)
Intestinal Neoplasms (Phase 3)
Intestinal Pseudo-Obstruction (Phase 4)
Intestines (Phase 4)
Irritable Bowel Syndrome (Phase 4)
Ketamine (Phase 3)
Laparoscopy (Phase 4)
Leukemia (Phase 3)
Leukemia, Eosinophilic, Acute (Phase 2)
Leukemia, Hairy Cell (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 2)
Leukemia, Myeloid, Acute (Phase 3)
Leukemia, Myeloid, Chronic-Phase (Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Leukemia, Neutrophilic, Chronic (Phase 2)
Lidocaine (Phase 3)
Liver Cirrhosis (Phase 1)
Lymphoma (Phase 3)
Lymphoma, B-Cell, Marginal Zone (Phase 2)
Lymphoma, Follicular (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 2)
Mental Health (Phase 2)
Methamphetamine (Phase 2)
Multiple Myeloma (Phase 3)
Myasthenia Gravis (Phase 2)
Mycobacterium avium Complex (Phase 2)
Myelodysplastic Syndromes (Phase 3)
Myeloproliferative Disorders (Phase 3)
Narcotic-Related Disorders (Phase 2)
Narcotics (Phase 4)
Nausea ()
Neoadjuvant Therapy (Phase 2)
Neonatal Abstinence Syndrome (Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 4)
Neoplastic Cells, Circulating (Phase 2)
Nephrolithotomy, Percutaneous (Early Phase 1)
Neuralgia (Phase 1/Phase 2)
Neuroblastoma (Phase 2)
Obsessive-Compulsive Disorder (Phase 4)
Ondansetron (Phase 4)
Ovarian Neoplasms (Phase 2)
Oximetry (Phase 3)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 3)
Parkinson Disease (Phase 2)
Pathologic Processes (Phase 3)
Personal Satisfaction (Phase 4)
Pharmacokinetics (Phase 3)
Poisoning (Phase 4)
Post-Concussion Syndrome (Phase 1)
Postoperative Complications (Phase 4)
Precancerous Conditions (Phase 3)
Pregnancy (Phase 2/Phase 3)
Pregnancy Complications (Phase 2)
Primary Myelofibrosis (Phase 2)
Prostatic Neoplasms (Phase 4)
Pruritus (Phase 4)
Psychological Distress (Phase 4)
Psychotic Disorders (Phase 2)
Quality of Life (Phase 2/Phase 3)
Respiratory Insufficiency (Phase 3)
Sarcoma (Phase 2)
Schizophrenia (Phase 3)
Sezary Syndrome (Phase 2)
Shivering (Phase 4)
Sleep Apnea, Obstructive (Phase 3)
Sleep Apnea Syndromes (Phase 3)
Testicular Neoplasms (Phase 2)
Tic Disorders (Phase 4)
Tobacco Use Disorder (Phase 2)
Tonsillectomy (Phase 3)
Tonsillitis (Phase 2)
Tourette Syndrome (Phase 4)
Tremor (Phase 4)
Uterine Cervical Neoplasms (Phase 3)
Vomiting (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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