Active Ingredient History

  • Now
Corifungin refers to the sodium salt of amphotericin B. Although amphotericin B has become the primary drug of choice for treating primary amoebic meningoencephalitis, its use is associated with multiple side effects, including use-limiting renal toxicity. Initial reports for the in vivo efficacy of corifungin in a mouse model of primary amoebic meningoencephalitis showed activity superior to that of amphotericin B at equivalent dosing. Chemically, corifungin is the sodium salt of amphotericin B with excellent aqueous solubility. The increased solubility of corifungin is likely to account for the described increase in activity. Acea Biotech is developing corifungin for the treatment of fungal infections and amebic diseases. Acea has completed of host of animal studies on corifungin setting the stage to take the drug into the clinic. U.S. FDA has approved orphan drug status for corifungin for the treatment of primary amebic meningoencephalitis.   NCATS

  • SMILES: C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)[C@@H](O)[C@@H](N)[C@@H]1O
  • Mol. Mass: 924.079
  • ALogP: 0.71
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral, Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$12.0600 - $33.2938
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

abelcet | abelecet | ambisome | amfotericina b | amophotericin b | amph-b | amphocin | ampho-moronal | amphotec | amphoteracin b | amphotercin b | amphotericin | amphotericin b | amphotericin b deoxycholate | amphotericin b - deoxycholate | amphotericin b-deoxycholate | amphotericin b, deoxycholate drug combination | amphotericin b lipid complex | amphotericin b liposome | amphotericine b | amphotéricine b | amphotericinum b | amphotericitin b | amphotreicin b | amphozone | ampotericin b | apothecon | c-amb | d-amb cpd | fungilin | fungilin in orabase | fungizone | hamb-doc | l-amb | liposomal amphotericin b | nsc527017 | nsc-527017


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