Active Ingredient History

  • Now
Zolmitriptan (Zomig; formerly 311C90) is a novel 5-hydroxytryptamine (5HT)1B/1D receptor agonist with proven efficacy in the acute treatment of migraine with or without preceding aura. The N-desmethyl metabolite also has high affinity for 5-HT1B/1D and moderate affinity for 5-HT1A receptors. Migraines are likely due to local cranial vasodilatation and/or to the release of sensory neuropeptides (vasoactive intestinal peptide, substance P and calcitonin gene-related peptide) through nerve endings in the trigeminal system. The therapeutic activity of Zomig for the treatment of migraine headache is thought to be due to the agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels (including the arterio-venous anastomoses) and sensory nerves of the trigeminal system, which result in cranial vessel constriction, and inhibition of pro-inflammatory neuropeptide release.   NCATS

  • Mol. Mass: 287.3568
  • ALogP: 1.92
  • ChEMBL Molecule:
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Drug Pricing (per unit)

United States

$0.9600 - $501.4100


$2.3026 - $2.8376
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

311c90 | 4-((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)-2-oxazolidinone | 4-[[3-(2-dimethylaminoethyl)-1h-indol-5-yl]methyl]oxazolidin-2-one | ascotop | astra brand of zolmitriptan | astrazeneca brand of zolmitriptan | ferrer brand of zolmitriptan | flezol | (s)-4-({3-[2-(dimethylamino)ethyl]-1h-indol-5-yl}methyl)-1,3-oxazolidin-2-one | zeneca brand of zolmitriptan | zipton | zolmitriptan | zolmitriptanum | zomig | zomigoro | zomig-zmt | zominat


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