Active Ingredient History

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Apatinib, also known as rivoceranib, is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2. It is an orally bioavailable, small molecule agent which is thought to inhibit angiogenesis in cancer cells; specifically, apatinib inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. This agent also mildly inhibits c-Kit and c-SRC tyrosine kinases.   Wikipedia

  • SMILES: O=C(Nc1ccc(cc1)C2(CCCC2)C#N)c3cccnc3NCc4ccncc4
  • Mol. Mass: 397.48
  • ALogP: 4.68
  • ChEMBL Molecules:
More Chemistry
apatinib | apatinib mesylate | yn968d1 | yn-968d1


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