Active Ingredient History

  • Now
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Furosemide inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic. Furosemide is sold under the brand name Lasix among others.   NCATS

  • SMILES: NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O
  • Mol. Mass: 330.744
  • ALogP: 1.89
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0163 - $3.8670
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid | 4-chloro-5-sulfamoyl-n-furfuryl-anthranilic acid | 4-chloro-n-(2-furylmethyl)-5-sulfamoylanthranilic acid | 4-chloro-n-furfuryl-5-sulfamoylanthranilic acid | aluzine 20 | aluzine 40 | aluzine 500 | aquamed | disal | diuresal | dryptal | froop | frumax | frumil | frusemide | frusetic | frusid | frusol | fupiram | furosemid | furosemida | furosemide | furosemidu | furosemidum | hydroled | lasix | lasix ret | lasix (tn) | lb-502 | rusyde | tenkofruse


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue