Active Ingredient History

  • Now
Vigabatrin is an anticonvulsant chemically unrelated to other anticonvulsants. Vigabatrin prevents the catabolism of GABA by irreversibly inhibiting the enzyme GABA transaminase. It is an analog of GABA, but it is not a receptor agonist. However, vigabatrin is not a potent inhibitor of GABA-T with a Ki of 10 mM. Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase, GABA-T). Duration of action is determined by rate of GABA-T re-synthesis. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active. Vigabatrin is sold under the trade name SABRIL, it is indicated as adjunctive therapy for adults and pediatric patients 10 years of age and older with refractory complex partial seizures who have inadequately responded to several alternative treatments and for whom the potential benefits outweigh the risk of vision loss.   NCATS

  • Mol. Mass: 129.157
  • ALogP: 0.36
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)


$0.6432 - $0.6940

United States

$104.6874 - $143.9146
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(+/-)-4-amino-5-hexenoic acid | 4-amino-5-hexenoic acid | cpp-109 | gamma vinyl gaba | gamma-vinyl gaba | gamma-vinyl-gamma-aminobutyric acid | gvg | mdl-71754 | sabril | vigabatrin | vigabatrina | vigabatrine | vigabatrin hcl | vigabatrin hydrochloride | vigabatrinum | vinyl gamma-aminobutyric acid


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