Active Ingredient History

  • Now
Verapamil is a FDA approved drug used to treat high blood pressure and to control chest pain. Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.   NCATS

  • SMILES: COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
  • Mol. Mass: 454.61
  • ALogP: 5.09
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$0.0498 - $16.7156


$0.0579 - $0.2982
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

berkatens | calan | calan sr | cordilox | cordilox i.v. | cordilox mr 240 | covera | covera-hs | cp-165331 | cp-16533-1 | d-365 | ethimil mr 240 | geangin | half securon sr | iproveratril | isoptin | isoptin sr | manidon sr | ranvera mr | rs-verapamil | securon | securon iv | securon mid | securon sr | tarka | univer | verapamil | (+/-)-verapamil | vérapamil | verapamil hcl | verapamil hydrochloride | verapamilo | verapamilum | verapress mr 240 | vera-til sr | verelan | verelan pm | vertab sr 240 | zolvera


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