Active Ingredient History

  • Now
Glycyrrhizin, a component of Chinese medicine licorice root. In Japan glycyrrhizin has been used for more than 20 years as treatment for chronic hepatitis and improves liver function with occasional complete recovery from hepatitis. In randomized controlled trials, glycyrrhizin induced a significant reduction of serum aminotransferases and an improvement in liver histology compared to placebo. Intravenous glycyrrhizin can be used safely and be useful for patients with difficult-to-diagnose acute liver disease as an 'initial' treatment tool to improve liver inflammation before starting disease-specific treatments. The mechanism of anti-inflammatory effect of glycyrrhizin most probably does not involve ROS and this major constituent is not responsible for the inhibition effects of liquorice extract on neutrophil functions.   NCATS

  • SMILES: CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(=O)O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(=O)O)C(=O)O
  • Mol. Mass: 822.94
  • ALogP: 2.25
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No
18beta-glycyrrhizic acid | (3 beta)-3-hydroxyurs-12-en-28-oic acid | 3-epi-ursolic acid | arthrodont | biosone | e958 | enoxolone | glycyron | glycyrrhetic acid | glycyrrhetin | glycyrrhetinic acid | glycyrrhetinic acid glycoside | glycyrrhizic acid | glycyrrhizin | glycyrrhizinate dipotassium | glycyrrhizinic acid | merotaine | nsc-35347 | nsc-35350 | rhetinic acid | subglycyrrhelinic acid | uralenic acid | ursolic acid | ursolic acid, (3beta)-isomer, 2-(14)c-labeled | ursolic acid, (3beta)-isomer, monopotassium salt


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