Active Ingredient History
Hydromorphone (also known as dihydromorphinone and the brand name Dilaudid among others) is a more potent opioid analgesic than morphine and is used for moderate to severe pain. It can be administered by injection, by infusion, by mouth, and rectally. Oral bioavailability is low. The kidney excretes hydromorphone and its metabolites. Some metabolites may have greater analgesic activity than hydromorphone itself but are unlikely to contribute to the pharmacological activity of hydromorphone. With the exception of pruritus, sedation and nausea and vomiting, which may occur less after hydromorphone than after morphine, the side-effects of these drugs are similar. Hydromorphone interacts predominantly with the opioid mu-receptors. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. It also binds with kappa and delta receptors which are thought to mediate spinal analgesia, miosis and sedation. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Pain (Phase 4)
Acute Pain (Phase 4)
Adolescent (Phase 4)
Analgesia (Phase 4)
Analgesia, Obstetrical (Phase 4)
Analgesia, Patient-Controlled (Phase 4)
Analgesics (Phase 3)
Analgesics, Opioid (Phase 4)
Anemia, Sickle Cell (Phase 4)
Anesthesia, Obstetrical (Phase 1)
Anti-Inflammatory Agents, Non-Steroidal (Phase 4)
Arterial Occlusive Diseases (Phase 2)
Arthroplasty (Phase 4)
Back Pain (Phase 3)
Behavior, Addictive (Phase 2)
Bile Duct Neoplasms (Phase 3)
Body Weight Changes (Phase 4)
Breast Diseases (Phase 3)
Breast Neoplasms (Phase 2)
Cancer Pain (Phase 4)
Cardiotoxicity (Phase 4)
Cesarean Section (Phase 4)
Chronic Pain (Phase 4)
Colonic Neoplasms (Phase 4)
Colorectal Surgery (Phase 4)
Constipation (Phase 4)
Coronary Disease (Phase 4)
Diverticulitis, Colonic (Phase 4)
Emergency Service, Hospital (Phase 4)
Fentanyl (Phase 4)
Fractures, Bone (Phase 4)
Funnel Chest (Phase 4)
Healthy Volunteers (Phase 4)
Hemoglobins (Phase 2)
Heroin Dependence (Phase 3)
Hydromorphone (Phase 4)
Ibuprofen (Phase 4)
Ileus (Phase 4)
Intensive Care Units (Phase 4)
Intestinal Pseudo-Obstruction (Phase 4)
Labor Pain (Phase 4)
Low Back Pain (Phase 4)
Lung Diseases (Phase 4)
Lymphoma (Phase 4)
Migraine Disorders (Phase 4)
Mucositis (Phase 3)
Multiple Trauma (Phase 3)
Musculoskeletal Diseases (Phase 2)
Nalbuphine (Phase 1)
Narcotics (Phase 4)
Nausea (Phase 4)
Neoplasm Metastasis (Phase 4)
Neoplasms (Phase 4)
Neuralgia (Phase 4)
Obesity (Phase 4)
Opiate Substitution Treatment (Phase 4)
Opioid-Related Disorders (Phase 3)
Orthopedic Procedures (Phase 2)
Osteoarthritis, Hip (Phase 3)
Osteoarthritis, Knee (Phase 3)
Pain ()
Pain, Postoperative (Phase 4)
Patient Satisfaction (Phase 4)
Pelvic Organ Prolapse (Phase 4)
Postoperative Complications (Phase 3)
Postoperative Hemorrhage (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Pregnancy (Phase 4)
Prostatic Neoplasms (Phase 3)
Rectal Neoplasms (Phase 4)
Renal Colic (Phase 4)
Respiratory Insufficiency (Phase 4)
Rib Fractures (Phase 4)
Rotator Cuff Injuries (Phase 4)
Sleep Apnea, Obstructive (Early Phase 1)
Spinal Injuries (Phase 3)
Substance Abuse, Oral (Phase 2)
Substance-Related Disorders (Phase 1)
Testicular Hydrocele (Phase 4)
Thoracic Surgery, Video-Assisted (Phase 4)
Tonsillitis (Early Phase 1)
Wound Healing (Phase 1/Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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