Active Ingredient History

  • Now
Hydromorphone (also known as dihydromorphinone and the brand name Dilaudid among others) is a more potent opioid analgesic than morphine and is used for moderate to severe pain. It can be administered by injection, by infusion, by mouth, and rectally. Oral bioavailability is low. The kidney excretes hydromorphone and its metabolites. Some metabolites may have greater analgesic activity than hydromorphone itself but are unlikely to contribute to the pharmacological activity of hydromorphone. With the exception of pruritus, sedation and nausea and vomiting, which may occur less after hydromorphone than after morphine, the side-effects of these drugs are similar. Hydromorphone interacts predominantly with the opioid mu-receptors. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. It also binds with kappa and delta receptors which are thought to mediate spinal analgesia, miosis and sedation.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0184 - $12.8930


$0.2555 - $24.2591
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

4,5alpha-epoxy-3-hydroxy-17-methyl-6-morphinanone | 4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one | (-)-(5r)-4,5-epoxy-3-hydroxy-9alpha-methylmorphinan-6-one | 6-deoxy-7,8-dihydro-6-oxomorphine | 7,8-dihydromorphinone | dihydromorfinon | dihydromorphinone | dihydromorphinone hcl | dihydromorphone | dihydroxymorphinone | dilaudid | dilaudid-hp | dimorphone | exalgo | hidromorfona | hydromorfona | hydromorphon | hydromorphone | hydromorphone hcl | hydromorphone hydrochloride | hydromorphonum | idromorfone | palladone | palladone-sr


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