Active Ingredient History
Pantoprazole is a proton pump inhibitor that inhibits gastric acid secretion and used for short-term treatment of erosive esophagitis associated with gastroesophageal reflux disease. Pantoprazole suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours. Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus for adults and pediatric patients 5 years of age and older caused by gastroesophageal reflux disease. It can be used as a maintenance therapy for long-term use after initial response is obtained, but there have not been any controlled studies about the use of pantoprazole past a duration of 12 months. Pantoprazole may also be used in combination with antibiotics to treat ulcers caused by Helicobacter pylori. Use of pantoprazole may increase the chance of developing infections such as pneumonia, particularly in hospitalized patients. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Pain (Phase 4)
Acute Coronary Syndrome (Phase 4)
Acute Kidney Injury (Phase 4)
Allergy and Immunology (Phase 2)
Aspergillosis (Phase 1)
Atrial Fibrillation (Phase 4)
Bacterial Infections (Phase 3)
Bile Reflux (Phase 4)
Brain Edema (Phase 2)
Breast Neoplasms (Phase 2)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronary Thrombosis (Phase 4)
Critical Illness (Phase 4)
Diabetes Mellitus (Phase 3)
Diabetes Mellitus, Type 1 (Phase 2)
Diabetes Mellitus, Type 2 (Phase 2/Phase 3)
Drug Interactions (Phase 4)
Dysbiosis (Phase 4)
Dyspepsia (Phase 4)
Emergencies (Phase 4)
Esophageal and Gastric Varices (Phase 4)
Esophageal Diseases (Phase 3)
Esophageal Neoplasms (Phase 3)
Esophagitis (Phase 4)
Eustachian Tube (Phase 4)
Fasting (Phase 1)
Gastrinoma (Phase 2)
Gastritis (Phase 3)
Gastrointestinal Hemorrhage (Phase 3)
Head and Neck Neoplasms (Phase 2)
Healthy Volunteers (Phase 4)
Heartburn (Phase 4)
Heart Failure (Phase 3)
Helicobacter Infections (Phase 4)
Helicobacter pylori (Phase 4)
Hemorrhage (Phase 4)
Hypertension, Portal (Phase 4)
Immunosuppression Therapy (Phase 4)
Inflammation (Phase 3)
Intestinal Neoplasms (Phase 4)
Kidney Failure, Chronic (Phase 4)
Laryngopharyngeal Reflux (Phase 4)
Liver Cirrhosis (Phase 4)
Mental Health (Phase 2/Phase 3)
Mucositis (Phase 2)
Multiple Sclerosis (Phase 1)
Nausea (Phase 4)
Neoplasms (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 4)
Obesity (Phase 1)
Osteosarcoma (Phase 2)
Ototoxicity (Phase 2)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Pediatric Obesity (Phase 4)
Peptic Ulcer ()
Peptic Ulcer Hemorrhage (Phase 4)
Pharmacokinetics (Phase 1)
Platelet Aggregation Inhibitors (Phase 4)
Prostatic Neoplasms (Phase 2)
Proton Pump Inhibitors (Phase 4)
Psychotic Disorders (Phase 4)
Purpura, Thrombocytopenic, Idiopathic (Phase 3)
Renal Replacement Therapy (Phase 4)
Respiratory Aspiration (Phase 4)
Rib Fractures (Phase 4)
Schizophrenia (Phase 2/Phase 3)
Sleep Apnea, Obstructive (Phase 4)
Sprains and Strains (Phase 3)
Stomach Diseases (Phase 4)
Stomach Ulcer (Phase 4)
Stroke (Phase 2)
Thrombosis (Phase 4)
Transplantation (Phase 4)
Ulcer (Phase 4)
Wounds and Injuries (Phase 4)
Zollinger-Ellison Syndrome (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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