Active Ingredient History

  • Now
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.   NCATS

  • SMILES: CCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(Cl)=C2Cl)C(=O)OC
  • Mol. Mass: 384.254
  • ALogP: 3.96
  • ChEMBL Molecule:
More Chemistry

Drug Pricing (per unit)


$0.0780 - $0.2427

United States

$0.2146 - $0.3643
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate | 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester | cabren | cardioplen xl | dl-felodipine | (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate | felodipina | felodipine | (+/-)-felodipine | felodipinum | felogen xl | felotens xl | flodil | folpik xl | h 154/82 | h-154/82 | keloc sr | neofel xl | parmid xl | pinefeld xl | plendil | preslow | (rs)-felodipine | vascalpha


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