Active Ingredient History

  • Now
Ropinirole (INN; trade names Requip, Repreve, Ronirol, Adartrel) is a dopamine agonist of the non-ergoline class of medications, used in the treatment of Parkinson's disease and restless legs syndrome. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate dopamine receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum. Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance. Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime. Unusual side effects specific to D3 agonists such as ropinirole and pramipexole can include hypersexuality, punding, and compulsive gambling, even in patients without a history of these behaviors.   NCATS

More Chemistry

Drug Pricing (per unit)

United States

$0.0584 - $9.6383
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

4-(2-(di-n-propylamino)ethyl)-2(3h)-indolone | adartrel | aimpart xl | glaxosmithkline brand of ropinirole hydrochloride | ipinnia xl | ralnea xl | raponer xl | repinex xl | requip | requip xl | ropilynz xl | ropinirol | ropinirole | ropinirole hcl | ropinirole hydrochloride | ropinirolum | ropinrole | ropirinole | sk&f 101468 | sk&f-101468 | sk&f-101,468 | skf 101468 | sk&f-101468a | sk&f-101468-a | smithkline beecham brand of ropinirole hydrochloride | spiroco xl


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue