Active Ingredient History

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Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine blocks sodium ion channels required for the initiation and conduction of neuronal impulses thereby affecting local anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.   NCATS

More Chemistry

Combination drugs

( tetracaine (pontocaine), lidocaine (xylocaine) - other name: pliaglis )
2-(dimethylamino)ethyl 4-(butylamino)benzoate | 2-(dimethylamino)ethyl p-(butylamino)benzoate | amethocaine | amethocaine hcl | ametop | diäthylaminoäthanol ester der p-butylaminobenzösäure | dicaine | laudocaine | lidocaine and tetracaine | medihaler-tetracaine | metraspray | p-(butylamino)benzoic acid β-(dimethylamino)ethyl ester | p-butylaminobenzoyl-2-dimethylaminoethanol | pontocaine | pontocaine hcl | tetracaína | tetracaine | tétracaïne | tetracaine hcl | tetracaine hydrochloride | tetracaine monohydrochloride


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