tazemetostat (Tazverik) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA
AACT DrugBank PubChem

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Tazemetostat (EPZ-6438) is a selective inhibitor of histone-lysine N-methyltransferase EZH2. The drug is under clinical development (phase II) for the treatment of Diffuse Large B Cell Lymphoma, Malignant Mesothelioma and Synovial Sarcoma.   NCATS

Chemistry

  • SMILES: CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O
  • InChIKey: NSQSAUGJQHDYNO-UHFFFAOYSA-N
  • Mol. Mass: 572.7376
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$47.8581
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

tazemetostat

Organizations (34)

Research & Development (34)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (49)

Approved Indications (1)


 

Soft Tissue Neoplasms (approved 2020)

Experimental Indications - Clinical Trial Phases 1-4 (48)


 

Carcinoma (Phase 2)

Carcinoma, Hepatocellular (Phase 1)

Carcinoma, Renal Cell (Phase 2)

Carcinoma, Transitional Cell (Phase 1/Phase 2)

Chordoma (Phase 2)

Colorectal Neoplasms (Phase 2)

COVID-19 (Phase 2)

Cytokine Release Syndrome (Phase 2)

Endometrial Neoplasms (Phase 2)

Ependymoma (Phase 2)

Glioma (Phase 2)

Hematologic Neoplasms (Phase 1)

Hepatoblastoma (Phase 2)

Histiocytosis, Langerhans-Cell (Phase 2)

Hodgkin Disease (Phase 2)

Hydrolases (Phase 2)

Kidney Diseases (Phase 2)

Liver Diseases (Phase 1)

Lymphoma (Phase 2)

Lymphoma, B-Cell (Phase 1/Phase 2)

Lymphoma, B-Cell, Marginal Zone (Phase 1)

Lymphoma, Follicular (Phase 3)

Lymphoma, Large B-Cell, Diffuse (Phase 2)

Lymphoma, Large-Cell, Immunoblastic (Phase 1/Phase 2)

Lymphoma, Mantle-Cell (Phase 1)

Lymphoma, Non-Hodgkin (Phase 2)

Medulloblastoma (Phase 2)

Melanoma (Phase 1/Phase 2)

Mesothelioma (Phase 2)

Mutation (Phase 2)

Neoplasm Metastasis (Phase 1/Phase 2)

Neoplasms (Phase 2)

Neoplasms, Germ Cell and Embryonal (Phase 2)

Nerve Sheath Neoplasms (Phase 2)

Neuroblastoma (Phase 2)

Neuroectodermal Tumors (Phase 2)

Osteosarcoma (Phase 2)

Ovarian Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 2)

Prostatic Neoplasms, Castration-Resistant (Phase 1)

Rhabdoid Tumor (Phase 2)

Rhabdomyosarcoma (Phase 2)

Sarcoma (Phase 3)

Sarcoma, Ewing (Phase 2)

Sarcoma, Synovial (Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 1/Phase 2)

Urinary Bladder Neoplasms (Phase 1/Phase 2)

Wilms Tumor (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 45
  • # of Trial Organizations: 34

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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