Active Ingredient History
Sulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam in combination with semisynthetic antibiotic ampicillin sodium is indicated for the treatment of infections due to susceptible strains of the designated microorganisms: Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli etc; Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K. Pneumoniae) tec; Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli, and Bacteroides spp. (including B. fragilis). NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Bacteroides Infections (approved 1988)
Haemophilus influenzae (approved 1988)
Moraxella catarrhalis (approved 1988)
Peptostreptococcus (approved 1988)
Staphylococcus aureus (approved 1988)
Staphylococcus epidermidis (approved 1988)
Abdominal Abscess (Phase 4)
Acinetobacter baumannii (Phase 3)
Acinetobacter Infections (Phase 4)
Appendicitis (Phase 4)
Bacteremia (Phase 3)
Bacterial Infections (Phase 4)
Breast Neoplasms (Phase 4)
Cholecystitis (Phase 4)
Cholecystitis, Acute (Phase 4)
Cholelithiasis (Phase 4)
Chorioamnionitis (Phase 2/Phase 3)
Cleft Palate (Phase 2)
Colitis, Ulcerative (Phase 2)
Critical Illness (Phase 4)
Drugs, Investigational (Phase 4)
Esophageal Achalasia (Phase 3)
Feeding and Eating Disorders (Phase 4)
Fractures, Open (Phase 4)
Gonorrhea (Phase 4)
Healthcare-Associated Pneumonia (Phase 3)
Healthy Volunteers (Phase 1)
Hemodialysis, Home (Phase 3)
HIV Infections (Phase 1/Phase 2)
Infections (Phase 4)
Intraabdominal Infections (Phase 4)
Jaw Fractures (Phase 1)
Lung Abscess (Phase 3)
Peritonitis (Phase 4)
Pneumonia (Phase 4)
Pneumonia, Aspiration (Phase 3)
Pneumonia, Bacterial (Phase 3)
Pneumonia, Ventilator-Associated (Phase 4)
Premature Birth (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Pyelonephritis (Phase 3)
Respiratory Tract Infections (Phase 4)
Skin Diseases, Bacterial (Phase 4)
Stomach Diseases (Phase 4)
Surgical Wound Infection (Phase 4)
Urinary Tract Infections (Phase 4)
Wound Infection (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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