Active Ingredient History

  • Now
Sulindac is a nonsteroidal anti-inflammatory agent (NSAIA) of the arylalkanoic acid class that is marketed in the U.S. by Merck as Clinoril. Like other NSAIAs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver enzymes. The sulfide metabolite then undergoes enterohepatic circulation; it is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAIA's except for drugs of the cyclooxygenase-2 (COX-2) inhibitor class. The exact mechanism of its NSAIA properties is unknown, but it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.   NCATS

  • SMILES: C[S+]([O-])C1=CC=C(\C=C2\C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1
  • Mol. Mass: 356.411
  • ALogP: 4.37
  • ChEMBL Molecules:
More Chemistry

Drug Pricing (per unit)

United States

$0.1063 - $0.2384
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1h-indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (z)- | (5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-(n-benzyl)-indene)-acetamide | aptosyn | cis-5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1h-indene-3-acetic acid | cis-5-fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid | clinoril | cp248 | cp 248 | exisulind | fgn-1 | mk231 | mk 231 | mk-231 | osip486823 | osip 486823 | osip-486823 | sulindac | sulindaco | sulindac sulfone | sulindac sulfone, (z)-isomer | sulindacum | varnish | (z)-5-fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1h-indene-3-acetic acid


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