API | sivelestat

sivelestat Report issue

Small molecule Experimental

AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW

Sivelestat is an inhibitor of human neutrophil elastase. ^Wikipedia

Chemistry

SMILES: O.O.O.O.[Na+].CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)[O-]
InChIKey: PLHREJBSQUSUCW-UHFFFAOYSA-M
Mol. Mass: 528.51
ALogP: 2.83 Partition coefficient
ChEMBL Molecules:

sivelestat sodium

sivelestat sodium

sivelestat

More Chemistry

Pharmacology

Mechanism of Action:
- Chymotrypsin-like elastase family member 1 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

Organizations (7)

Research & Development (7)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (5)

Approved Indications (2)

Acute Lung Injury

Respiratory Distress Syndrome

Experimental Indications - Clinical Trial Phases 1-4 (5)

Acute Lung Injury (Phase 4)

Community-Acquired Infections (Phase 2)

Respiratory Distress Syndrome (Phase 4)

Severe Acute Respiratory Syndrome (Phase 3)

Systemic Inflammatory Response Syndrome (Phase 4)

Overview

Highest Phase: Phase 4
# of Trials: 8
# of Trial Organizations: 7

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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