Active Ingredient History
Cyclosporins are cyclic polypeptide macrolides that were originally derived from the soil fungus Tolypocladium inflatum. Cyclosporine (also known as cyclosporine A) was discovered by Sandoz and developed for the tretment of immune disorders. The drug was approved by FDA for such diseases as Rheumatoid Arthritis, Psoriasis (Neoral), Keratoconjunctivitis sicca (Restasis) and prevention of transplant rejections (Neoral and Sandimmune). Cyclosporine’s primary immunosuppressive mechanism of action is inhibition of T-lymphocyte function. Upon administration cyclosporine binds to cyclophilin A and thus inhibits calcineurin, leading to immune system suppression. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Arthritis, Rheumatoid (approved 1995)
Graft Rejection (approved 1983)
Keratoconjunctivitis Sicca (approved 2003)
Psoriasis (approved 1995)
Abortion, Habitual (Phase 2/Phase 3)
Acne Vulgaris (Phase 3)
Acute Kidney Injury (Phase 4)
Adenosine Deaminase (Phase 1)
Adrenoleukodystrophy (Phase 2)
Allergy and Immunology (Phase 1/Phase 2)
Allografts (Phase 4)
Alopecia Areata (Phase 2/Phase 3)
alpha-Mannosidosis (Phase 2)
Anaplasia (Phase 4)
Anemia (Phase 2)
Anemia, Aplastic (Phase 4)
Anemia, Diamond-Blackfan (Phase 2)
Anemia, Hemolytic (Phase 2)
Anemia, Hemolytic, Autoimmune (Phase 3)
Anemia, Refractory (Phase 2)
Anemia, Sickle Cell (Phase 2)
Angioedemas, Hereditary (Phase 1)
Aortic Aneurysm, Abdominal (Phase 2)
Arthritis, Rheumatoid (Phase 4)
Aspartylglucosaminuria (Phase 2)
Aspergillosis (Phase 1)
Autoimmune Diseases (Phase 2)
Behcet Syndrome (Phase 3)
beta-Thalassemia (Phase 4)
Bone Marrow Cells (Phase 2)
Bone Marrow Failure Disorders (Phase 2)
Bone Marrow Transplantation (Phase 4)
Brain Death (Phase 4)
Brain Injuries, Traumatic (Phase 1/Phase 2)
Brain Neoplasms (Phase 1)
Breast Neoplasms (Phase 3)
Bronchiolitis (Phase 3)
Bronchiolitis Obliterans (Phase 3)
Burkitt Lymphoma (Phase 2)
Carcinoma, Giant Cell (Phase 2)
Carcinoma, Hepatocellular (Phase 3)
Carcinoma, Renal Cell (Phase 1/Phase 2)
Cardiac Surgical Procedures (Phase 1)
Cardiomegaly (Phase 2)
Cardiomyopathy, Hypertrophic (Phase 2)
Cardiopulmonary Bypass (Phase 2)
Cardiovascular Diseases (Phase 4)
Cataract (Phase 4)
Central Nervous System Neoplasms (Phase 1)
Cerebellum (Phase 2)
Chediak-Higashi Syndrome (Phase 2)
Cholesterol (Phase 1)
Chromosome Aberrations (Phase 2)
Chronic Disease (Phase 2)
Colitis, Ulcerative (Phase 4)
Colorectal Neoplasms (Phase 3)
Conjunctival Diseases (Phase 4)
Conjunctivitis (Phase 4)
Conjunctivitis, Allergic (Phase 4)
Corneal Diseases (Phase 3)
Corneal Transplantation (Phase 3)
Coronary Artery Bypass (Phase 2)
COVID-19 (Phase 4)
Cystitis, Interstitial (Phase 2)
Cytokine Release Syndrome (Phase 3)
Deficiency Diseases (Phase 2)
Delayed Graft Function (Phase 2)
Dermatitis, Atopic (Phase 4)
Dermatomyositis (Phase 3)
Desmoplastic Small Round Cell Tumor (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 3)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Nephropathies (Phase 4)
DiGeorge Syndrome (Phase 1/Phase 2)
Disease Progression (Phase 4)
Drug Evaluation (Phase 4)
Drug Hypersensitivity Syndrome (Early Phase 1)
Drug Interactions (Phase 1)
Drug-Related Side Effects and Adverse Reactions (Phase 1/Phase 2)
Drugs, Investigational (Phase 2)
Dry Eye Syndromes (Phase 4)
Dyskeratosis Congenita (Phase 2)
Eczema (Phase 3)
Endocardial Cushion Defects (Phase 3)
Endothelium (Phase 4)
End Stage Liver Disease (Phase 4)
Epidermolysis Bullosa (Phase 2)
Everolimus (Phase 2/Phase 3)
Eye Diseases (Phase 4)
Fallopian Tube Neoplasms (Phase 2)
Fanconi Anemia (Phase 2)
Fasting (Phase 2/Phase 3)
Fibrosis (Phase 4)
Fucosidosis (Phase 2)
Gangliosidosis, GM1 (Phase 2)
General Surgery (Phase 3)
Genetic Diseases, Inborn (Phase 1)
Glaucoma, Open-Angle (Phase 2)
Glomerulonephritis, Membranous (Phase 3)
Glomerulosclerosis, Focal Segmental (Phase 3)
Graft Rejection (Phase 4)
Graft vs Host Disease (Phase 4)
Granulomatous Disease, Chronic (Phase 2)
Hair (Phase 2)
Hamartoma (Phase 2)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 3)
Heart Transplantation (Phase 4)
Hematologic Diseases (Phase 2)
Hematologic Neoplasms (Phase 1/Phase 2)
Hematopoietic Stem Cell Transplantation (Phase 4)
Hemoglobinopathies (Phase 2)
Hemoglobinuria (Phase 2)
Hemoglobinuria, Paroxysmal (Phase 2)
Hepacivirus (Phase 1)
Hepatitis, Autoimmune (Phase 4)
Hepatitis C (Phase 4)
Hepatitis C, Chronic (Phase 4)
Histiocytosis, Langerhans-Cell (Phase 2)
HIV (Phase 4)
HIV Infections (Phase 2)
HIV Seropositivity (Phase 4)
Hodgkin Disease (Phase 3)
Hyperkalemia (Phase 1)
Hyperlipoproteinemia Type I (Phase 2/Phase 3)
Hypoglycemia (Phase 1/Phase 2)
IgA Vasculitis (Phase 4)
Immune System Diseases (Phase 1)
Immunoglobulin Light-chain Amyloidosis (Phase 1/Phase 2)
Immunologic Deficiency Syndromes (Phase 2)
Immunosuppression Therapy (Phase 4)
Infections (Phase 4)
Inflammation (Phase 4)
Intestinal Neoplasms (Phase 1)
Intraocular Lymphoma (Phase 2)
Islets of Langerhans Transplantation (Phase 3)
Keratitis (Phase 4)
Keratoconjunctivitis Sicca (Phase 4)
Keratomileusis, Laser In Situ (Phase 2)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Kidney Glomerulus (Phase 2)
Kidney Neoplasms (Phase 2)
Kidney Transplantation (Phase 4)
Lacrimal Apparatus Diseases (Phase 2/Phase 3)
Leprosy (Phase 2/Phase 3)
Leukemia (Phase 3)
Leukemia, Biphenotypic, Acute (Phase 2)
Leukemia, Eosinophilic, Acute (Phase 3)
Leukemia, Hairy Cell (Phase 2)
Leukemia, Large Granular Lymphocytic (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 3)
Leukemia, Lymphoid (Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 2)
Leukemia, Mast-Cell (Phase 2)
Leukemia, Monocytic, Acute (Phase 3)
Leukemia, Myeloid (Phase 3)
Leukemia, Myeloid, Acute (Phase 4)
Leukemia, Myeloid, Chronic-Phase (Phase 2)
Leukemia, Myelomonocytic, Acute (Phase 3)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Leukemia, Myelomonocytic, Juvenile (Phase 2)
Leukemia, Prolymphocytic (Phase 3)
Leukemia, Prolymphocytic, B-Cell (Phase 2)
Leukemia, Prolymphocytic, T-Cell (Phase 3)
Leukemia, T-Cell (Phase 1)
Leukodystrophy, Globoid Cell (Phase 2)
Leukodystrophy, Metachromatic (Phase 2)
Livedoid Vasculopathy (Phase 4)
Liver Cirrhosis, Biliary (Phase 4)
Liver Diseases (Phase 2)
Liver Transplantation (Phase 4)
Living Donors (Phase 3)
Lung Diseases (Phase 2)
Lung Transplantation (Phase 4)
Lupus Erythematosus, Systemic (Phase 2)
Lupus Nephritis (Phase 3)
Lymphocytes (Phase 1/Phase 2)
Lymphocytosis (Phase 1)
Lymphohistiocytosis, Hemophagocytic (Phase 3)
Lymphoma (Phase 3)
Lymphoma, B-Cell (Phase 2)
Lymphoma, B-Cell, Marginal Zone (Phase 2)
Lymphoma, Follicular (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 3)
Lymphoma, Large-Cell, Anaplastic (Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 3)
Lymphoma, Mantle-Cell (Phase 3)
Lymphoma, Non-Hodgkin (Phase 3)
Lymphoma, T-Cell (Phase 2)
Lymphoma, T-Cell, Cutaneous (Phase 2)
Lymphoma, T-Cell, Peripheral (Phase 2)
Lymphomatoid Granulomatosis (Phase 2)
Lymphoproliferative Disorders (Phase 2)
Meibomian Gland Dysfunction (Phase 4)
Melanoma (Phase 2)
Metabolic Diseases (Phase 2)
Mucolipidoses (Phase 2)
Mucopolysaccharidoses (Phase 2)
Mucopolysaccharidosis I (Phase 2)
Mucopolysaccharidosis II (Phase 2)
Mucopolysaccharidosis III (Phase 2)
Mucopolysaccharidosis VI (Phase 2)
Mucopolysaccharidosis VII (Phase 2)
Multiple Myeloma (Phase 3)
Mycoses (Phase 2)
Myelodysplastic Syndromes (Phase 4)
Myeloproliferative Disorders (Phase 3)
Myocardial Infarction (Phase 3)
Myocardial Reperfusion Injury (Phase 2)
Myocarditis (Phase 2)
Myositis (Phase 2)
Nails (Phase 2)
Neoplasm Metastasis (Phase 1)
Neoplasm, Residual (Phase 1/Phase 2)
Neoplasms (Phase 2)
Neoplasms, Neuroepithelial (Early Phase 1)
Neoplasms, Plasma Cell (Phase 2)
Nephrotic Syndrome (Phase 2)
Nerve Sheath Neoplasms (Phase 2)
Neural Tube Defects (Phase 2)
Neuroblastoma (Phase 2)
Neutropenia (Phase 2)
Neutrophils (Phase 2)
Optic Atrophy, Hereditary, Leber (Phase 2)
Organ Transplantation (Phase 4)
Osteogenesis Imperfecta (Phase 1)
Osteopetrosis (Phase 2/Phase 3)
Ovarian Neoplasms (Phase 2)
Pancytopenia (Phase 2)
Panuveitis (Phase 3)
Paraparesis, Tropical Spastic (Phase 2/Phase 3)
Periodontitis (Phase 2)
Peroxisomal Disorders (Phase 2)
Pharmacokinetics (Phase 2)
Pharmacology (Early Phase 1)
Phenylketonurias (Phase 1/Phase 2)
Plasmacytoma (Phase 2)
Polycythemia Vera (Phase 2)
Polyomavirus Infections (Phase 4)
Precancerous Conditions (Phase 2)
Primary Immunodeficiency Diseases (Phase 2)
Primary Myelofibrosis (Phase 2)
Primary Prevention (Phase 3)
Prostatic Neoplasms (Phase 3)
Proteinuria (Phase 2)
Psoriasis (Phase 4)
Pterygium (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 1/Phase 2)
Pulmonary Fibrosis (Phase 3)
Purpura, Thrombocytopenic, Idiopathic (Phase 3)
Purpura, Thrombotic Thrombocytopenic (Phase 3)
Recurrence (Phase 3)
Remission, Spontaneous (Phase 2)
Renal Artery Obstruction (Phase 2)
Renal Dialysis (Phase 4)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Renal Replacement Therapy (Phase 4)
Respiratory Syncytial Virus Infections (Phase 1)
Retinal Vasculitis (Phase 3)
Retinoblastoma (Phase 2)
Rhabdomyosarcoma (Phase 2)
Rosacea (Phase 4)
Sandhoff Disease (Phase 2)
Sarcoma (Phase 2)
Sarcoma, Ewing (Phase 2)
Severe Acute Respiratory Syndrome (Phase 2)
Severe Combined Immunodeficiency (Phase 1)
Severity of Illness Index (Phase 4)
Sezary Syndrome (Phase 2)
Sjogren's Syndrome (Phase 4)
Skin Neoplasms (Phase 4)
Sphingolipidoses (Phase 2)
Staining and Labeling (Phase 4)
Steroids (Phase 4)
Stevens-Johnson Syndrome (Phase 4)
Stroke (Phase 2)
Survival (Phase 3)
Tay-Sachs Disease (Phase 2)
Tears (Phase 4)
Testicular Neoplasms (Phase 2)
Thrombocythemia, Essential (Phase 2)
Thrombocytopenia (Phase 2)
Thrombosis (Phase 2)
Thymoma (Phase 2)
Transplantation (Phase 4)
Transplantation, Autologous (Phase 2)
Transplantation, Homologous (Phase 2)
Urination Disorders (Phase 2)
Urticaria (Phase 1/Phase 2)
Uterine Cervical Neoplasms (Phase 2)
Uveitis (Phase 3)
Uveitis, Posterior (Phase 3)
Vaginal Neoplasms (Phase 2)
Vascular Grafting (Phase 3)
Virus Diseases (Phase 4)
Waldenstrom Macroglobulinemia (Phase 3)
Wolman Disease (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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