Active Ingredient History

  • Now
Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin.   Wikipedia

  • Mol. Mass: 301.52
  • ALogP: 4.15
  • ChEMBL Molecule:
More Chemistry
2-aminooctadecane-1,3-diol | dihydrosphingosine | erythro-d-sphinganine | safingol | safingol hcl | safingol hydrochloride | safingol, (r-(r*,r*))-isomer | safingol, ((r*,s*)-(+-))-isomer | safingol, (s-(r*,s*))-isomer | saginfol | spc 100270 | spc-100270 | sphinganine | threo-dihydrosphingosine


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