Active Ingredient History

NOW
  • Now
Levobupivacaine (CHIROCAINE®) is a (S)-enantiomer of bupivacaine and it is related chemically and pharmacologically to the amino amide class of local anesthetics. Local anesthetics block the generation and the conduction of nerve impulses by increasing the threshold for electrical excitation in the nerve, by slowing propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: 1) pain, 2) temperature, 3) touch, 4) proprioception and 5) skeletal muscle tone. Levobupivacaine (CHIROCAINE®) is a safer alternative for regional anesthesia than bupivacaine. It demonstrated less affinity and strength of depressant effects onto myocardial and central nervous vital centers in pharmacodynamic studies, and a superior pharmacokinetic profile.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Combination drugs

|
( epinephrine (levophed), levobupivacaine (chirocaine) - other names: bupivacaine hydrochloride and epinephrine, marcaine hydrochloride w/ epinephrine preservative free, sensorcaine )
|
1-butyl-2',6'-pipecoloxylidide | 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide | anekain | bucain | bupivacaina | bupivacaine | (-)-bupivacaine | (+/-)-bupivacaine | (±)-bupivacaine | bupivacaine hcl | bupivacaine hydrochloride | bupivacaine hydrochloride anhydrous | bupivacaine hydrochloride kit | bupivacaine / lidocaine | bupivacainum | bupivac hcl | bupivaciane | bupivan | bupivicaine | carbostesin | chirocain | chirocaine | dl-1-butyl-2',6'-pipecoloxylidide | dl-bupivacaine | exparel | l-(-)-1-butyl-2',6'-pipecoloxylidide | lac-43 | l-(-)-bupivacaine | levobupivac | levobupivacaine | levo-bupivacaine | levobupivacaine hcl | levobupivacaine hydrochloride | levobupivicaine | marcain | marcaine | marcaine hcl | racemic bupivacaine | (rs)-bupivacaine | (s)-1-butyl-2',6'-pipecoloxylidide | (s)-bupivacaine | sensorcaine | sky0402 | sky-0402 | win-11318

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue