Active Ingredient History

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Velneperit (S-2367) is a drug developed by Shionogi, which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y5. It has anorectic effects and was developed as a possible treatment for obesity, but was discontinued from further development after disappointing results in Phase II clinical trials. However it was still considered a successful proof of concept of the potential of Y5 receptor antagonists as possible anti-obesity agents in future.   Wikipedia

  • SMILES: CC(C)(C)S(=O)(=O)N[C@@H]1CC[C@H](CC1)C(=O)Nc2ccc(cn2)C(F)(F)F
  • Mol. Mass: 407.46
  • ALogP: 3.32
  • ChEMBL Molecule:
More Chemistry
s-2367 | velneperit


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