Active Ingredient History
Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. It is FDA approved for the prophylaxis of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection. Multiple dosing of rifabutin has been associated with induction of hepatic metabolic enzymes of the CYP3A subfamily. Rifabutin’s predominant metabolite (25-desacetyl rifabutin: LM565), may also contribute to this effect. Similarly, concomitant medications that competitively inhibit the CYP3A activity may increase plasma concentrations of rifabutin. Common adverse reactions include discoloration of skin, rash, diarrhea, disorder of taste, indigestion, loss of appetite, nausea, vomiting, increased liver aminotransferase level (mild), ocular discoloration, uveitis, abnormal color of body fluid. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Mycobacterium avium-intracellulare Infection (approved 1992)
Analgesics, Opioid (Phase 1)
Bacterial Infections (Phase 3)
Chlamydia (Phase 2)
Coronary Disease (Phase 2)
Crohn Disease (Phase 4)
Drug Interactions (Phase 4)
Drug Resistance, Bacterial (Phase 3)
Drugs, Investigational (Phase 1)
Dyspepsia (Phase 3)
Gastritis (Phase 3)
Healthy Volunteers (Phase 1)
Helicobacter Infections (Phase 3)
Helicobacter pylori (Phase 4)
HIV (Phase 2)
Infections (Phase 3)
Kidney Failure, Chronic (Phase 1)
Lung Diseases (Phase 3)
Male (Phase 1)
Multiple Sclerosis, Relapsing-Remitting (Phase 2)
Mycobacterium (Phase 1)
Mycobacterium avium Complex (Phase 4)
Mycoses (Phase 3)
Respiratory Tract Infections (Phase 4)
Sprains and Strains (Phase 3)
Staphylococcus aureus (Phase 2)
Tuberculosis (Phase 4)
Tuberculosis, Pulmonary (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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