Active Ingredient History

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Esmethadone, also known as dextromethadone, is the (S)-enantiomer of methadone. It acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist. Unlike levomethadone, it has low affinity for opioid receptors and lacks significant respiratory depressant action and abuse liability. Esmethadone is under development for the treatment of major depressive disorder. There is an asymmetric synthesis available to prepare both esmethadone and levomethadone.   Wikipedia

  • SMILES: CCC(=O)C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
  • InChIKey: USSIQXCVUWKGNF-KRWDZBQOSA-N
  • Mol. Mass: 309.4452
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry
dextromethadone

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