Active Ingredient History
The alkaloid L-(-)-scopolamine [L-(-)-hyoscine], a belladonna alkaloid, competitively inhibits muscarinic receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both peripheral antimuscarinic properties and central sedative, antiemetic, and amnestic effects. Scopolamine acts: i) as a competitive inhibitor at postganglionic muscarinic receptor sites of the parasympathetic nervous system, and ii) on smooth muscles that respond to acetylcholine but lack cholinergic innervation. It has been suggested that scopolamine acts in the central nervous system (CNS) by blocking cholinergic transmission from the vestibular nuclei to higher centers in the CNS and from the reticular formation to the vomiting center. Scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. Scopolamine is used for premedication in anesthesia and for the prevention of nausea and vomiting (post operative and associated with motion sickness). NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Motion Sickness (approved 1979)
Abdomen, Acute (Phase 3)
Abdominal Pain (Phase 4)
Acute Pain (Phase 2)
Alzheimer Disease (Phase 1)
Amyotrophic Lateral Sclerosis (Phase 2)
Analgesia, Obstetrical (Phase 2)
Bile Duct Diseases (Phase 3)
Bipolar Disorder (Phase 2)
Bradycardia (Phase 4)
Cerebral Palsy (Phase 3)
Cesarean Section (Phase 4)
Child (Phase 3)
Colic (Phase 4)
Colonic Polyps (Phase 4)
Delivery, Obstetric (Phase 4)
Dementia (Phase 1)
Depression (Phase 4)
Depressive Disorder (Phase 2)
Depressive Disorder, Major (Phase 4)
Dyspepsia (Phase 4)
Emergencies (Phase 4)
Endometrial Neoplasms (Phase 1/Phase 2)
Endoscopy (Phase 2/Phase 3)
Family Planning Services (Phase 4)
Gastroenteritis (Phase 4)
Gastrointestinal Diseases (Phase 2)
Hallucinations (Early Phase 1)
Healthy Volunteers (Phase 4)
Hypertriglyceridemia (Phase 3)
Intestinal Diseases (Phase 3)
Labor, Obstetric (Phase 4)
Labor Pain (Phase 2/Phase 3)
Labor Stage, First (Phase 4)
Laparoscopy (Phase 4)
Lung Diseases (Phase 2)
Memory Disorders (Phase 1)
Motion Sickness (Phase 3)
Nausea (Phase 4)
Neoplasms (Phase 4)
Ovarian Neoplasms (Phase 1/Phase 2)
Pain (Phase 4)
Pancreatic Diseases (Phase 3)
Patients (Phase 4)
Personal Satisfaction (Phase 4)
Phobia, Social (Phase 1)
Psychotic Disorders (Early Phase 1)
Renal Colic (Phase 1)
Scopolamine (Phase 2)
Sialorrhea (Phase 1/Phase 2)
Vomiting (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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