Active Ingredient History

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Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. Side effects include dizziness, drowsiness, weakness, nervousness, hallucinations, depression, vomiting, dry mouth, constipation, diarrhea, stomach pain, heartburn, increased muscle spasms, back pain, rash, sweating, and a tingling sensation in the arms, legs, hands, and feet.   NCATS

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Drug Pricing (per unit)

United States

$0.0347 - $5.2119
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2,1,3-benzothiadiazol-4-amine, 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)- | 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole | 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole | acorda brand of tizanidine hydrochloride | an021 | an-021 | ds 103-282 | ds-103-282 | ds103-282 | novartis brand of tizanidine hydrochloride | sanofi synthelabo brand of tizanidine hydrochloride | sirdalud | sirdalud mr | tizanidin | tizanidina | tizanidine | tizanidine hcl | tizanidine hydrochloride | tizanidine monohydrochloride | tizanidinum | zanaflex


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