Active Ingredient History
Tocopherol (alpha tocopheryl nicotinate) is an ester of tocopherol and nicotinic acid. Vitamin E (Tocopherol) is sold commercially as the esterified form (alpha tocopheryl acetate, alpha tocopheryl succinate and alpha tocopheryl nicotinate). Alpha tocopheryl nicotinate has antioxidant and vasodilatory properties. It can be used as a mild warming agent, without producing the redness typical for nicotinic acid. Tocopherol (alpha tocopheryl nicotinate) has been available in Japan since 1967. Tocopherol under the brand name Juvela N is approved in Japan for the treatment of symptoms accompanying hypertension, hyperlipidemia, peripheral circulatory disturbance resulting from arteriosclerosis obliterans. Tocopherol has being shown to inhibit platelet aggregation. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Arteriosclerosis Obliterans (approved 1966)
Avitaminosis (approved 2000)
Hyperlipidemias (approved 1966)
Hypertension (approved 1966)
Sunburn (approved 2014)
Acute Coronary Syndrome (Phase 3)
Acute Kidney Injury (Phase 2)
Adrenoleukodystrophy (Phase 2)
Aging (Phase 1)
Allergy and Immunology (Phase 1)
Alzheimer Disease (Phase 3)
Amyotrophic Lateral Sclerosis (Phase 3)
Anemia (Phase 2)
Anemia, Iron-Deficiency (Phase 1)
Anemia, Sickle Cell (Phase 4)
Angina Pectoris (Phase 4)
Angina, Stable (Phase 3)
Angina, Unstable (Phase 3)
Antioxidants (Phase 4)
Arterial Occlusive Diseases (Phase 3)
Asthenozoospermia (Phase 2/Phase 3)
Asthma (Phase 2)
Atherosclerosis (Phase 2/Phase 3)
Bites and Stings (Phase 3)
Brain Injuries (Phase 2)
Breast Neoplasms (Phase 3)
Burning Mouth Syndrome (Early Phase 1)
Burns (Phase 2/Phase 3)
CADASIL (Phase 2)
Cardiovascular Diseases (Phase 3)
Carotid Artery Diseases (Phase 2)
Cataract (Phase 3)
Catheters (Phase 3)
Central Serous Chorioretinopathy (Phase 2)
Cerebrovascular Disorders (Phase 3)
Cicatrix (Early Phase 1)
Cicatrix, Hypertrophic (Phase 4)
Cognition Disorders (Phase 3)
Colitis, Ulcerative (Phase 2)
Colorectal Neoplasms (Phase 3)
Coronary Artery Disease (Phase 3)
Coronary Disease (Phase 3)
Coronavirus Infections (Phase 3)
COVID-19 (Phase 3)
Critical Illness (Phase 3)
Crohn Disease (Phase 2)
Cystic Fibrosis (Phase 2)
Deficiency Diseases (Phase 2)
Delirium (Phase 3)
Depression (Phase 3)
Dermatology (Phase 1)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Foot (Phase 2/Phase 3)
Diabetic Retinopathy (Phase 3)
Down Syndrome (Phase 3)
Dry Eye Syndromes (Phase 4)
Dyslipidemias (Phase 4)
Dysmenorrhea (Phase 3)
Eclampsia (Phase 3)
Endometriosis (Phase 2)
Endothelial Cells (Phase 1/Phase 2)
End Stage Liver Disease (Early Phase 1)
Epilepsy (Phase 4)
Erectile Dysfunction (Phase 2)
Esophageal Mucosa (Early Phase 1)
Exercise Tolerance (Phase 2/Phase 3)
Fatty Liver (Phase 4)
Fibrosis (Phase 3)
Fragile X Syndrome (Phase 3)
Friedreich Ataxia (Phase 2)
General Surgery (Early Phase 1)
Glaucoma (Phase 3)
Graves Ophthalmopathy (Phase 2/Phase 3)
Head and Neck Neoplasms (Phase 3)
Healthy Volunteers (Phase 1)
Hearing Loss, Noise-Induced (Phase 2)
Heart Diseases (Phase 3)
Heart Failure (Phase 1)
Helicobacter pylori (Phase 4)
HELLP Syndrome (Phase 3)
Hemorrhage (Phase 3)
Hepatitis B, Chronic (Phase 4)
Hepatitis C, Chronic (Phase 3)
HIV Infections (Phase 2)
Hypersensitivity (Phase 1)
Hypertension (Phase 1)
Hypertension, Pulmonary (Phase 1)
Hypertrophy, Left Ventricular (Phase 4)
Hypobetalipoproteinemias (Phase 3)
Infant, Newborn (Phase 1)
Infant, Premature (Phase 4)
Infant, Small for Gestational Age (Phase 1)
Infant, Very Low Birth Weight (Phase 1)
Infertility, Female (Early Phase 1)
Infertility, Male (Phase 4)
Inflammation (Phase 2/Phase 3)
Influenza A Virus, H1N1 Subtype (Phase 4)
Insulin (Phase 2)
Insulin Resistance (Phase 2/Phase 3)
Intracranial Arteriosclerosis (Phase 2)
Intracranial Hemorrhages (Phase 1)
Iron Deficiencies (Phase 1)
Keloid (Phase 4)
Kidney Calculi (Phase 4)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 4)
Leukemia (Phase 1/Phase 2)
Lichen Planus, Oral (Phase 1)
Live Birth (Phase 4)
Liver Cirrhosis (Phase 2)
Liver Diseases (Phase 3)
Lung Diseases (Phase 3)
Lung Diseases, Obstructive (Phase 3)
Lung Neoplasms (Phase 3)
Lymphedema (Phase 4)
Macular Degeneration (Phase 3)
Macular Edema (Phase 1)
Malaria (Phase 3)
Meniere Disease (Phase 4)
Metabolic Syndrome (Phase 3)
Migraine Disorders (Phase 3)
Multiple Sclerosis (Phase 1/Phase 2)
Mycobacterium tuberculosis (Phase 3)
Myelodysplastic Syndromes (Phase 1/Phase 2)
Myeloproliferative Disorders (Phase 1/Phase 2)
Myocardial Infarction (Phase 3)
Myocardial Ischemia (Phase 3)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 3)
Neuromuscular Diseases (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Early Phase 1)
Ophthalmology (Phase 4)
Osteonecrosis (Phase 3)
Osteoradionecrosis (Phase 4)
Ovarian Neoplasms (Phase 1/Phase 2)
Oxidative Stress (Phase 4)
Pain (Phase 3)
Pain, Postoperative (Phase 3)
Pancreatic Neoplasms (Phase 1)
Pancreatitis (Phase 2/Phase 3)
Parenteral Nutrition (Phase 4)
Parkinson Disease (Phase 3)
Pediatric Obesity (Phase 4)
Penile Induration (Phase 1)
Peripheral Nervous System Diseases (Phase 2)
Poisoning (Phase 2)
Polycystic Ovary Syndrome (Phase 2)
Postmenopause (Phase 3)
Precancerous Conditions (Phase 3)
Pre-Eclampsia (Phase 3)
Pregnancy (Phase 3)
Pregnancy Complications (Phase 2)
Prostatic Neoplasms (Phase 3)
Psychotic Disorders (Phase 2/Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 3)
Purpura, Thrombocytopenic, Idiopathic (Phase 2/Phase 3)
Radiation Oncology (Phase 3)
Renal Dialysis (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Reperfusion Injury (Phase 2)
Restless Legs Syndrome (Phase 2/Phase 3)
Retinitis Pigmentosa (Phase 3)
Rhinitis, Allergic (Phase 1)
Schizophrenia (Phase 3)
Semen Analysis (Phase 4)
Shock, Septic (Phase 3)
Short Bowel Syndrome (Phase 2)
Skin Care (Early Phase 1)
Sleep Apnea Syndromes (Early Phase 1)
Smoking (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 1)
Steatitis (Phase 4)
Stomatitis (Phase 2)
Subarachnoid Hemorrhage (Phase 3)
Surgical Wound Infection (Phase 3)
Thoracic Surgery (Phase 3)
Thrombocytopenia (Phase 1/Phase 2)
Urinary Bladder Neoplasms (Phase 3)
Uveitis (Phase 1)
Vascular Diseases (Phase 3)
Vertigo (Phase 4)
Vitamin E Deficiency (Phase 2)
Work (Phase 3)
Wounds and Injuries (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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