Active Ingredient History
Carboplatin is an organoplatinum compound that possesses antineoplastic activity. Carboplatin is an intravenously administered platinum coordination complex and alkylating agent, which is used as a chemotherapeutic agent for the treatment of various cancers, mainly of advanced ovarian. Carboplatin is indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin. In addition this drug can be used to treat others cancers. Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent liver injury. Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific. The aquation of carboplatin, which is thought to produce the active species, occurs at a slower rate than in the case of cisplatin. Despite this difference, it appears that both carboplatin and cisplatin induce equal numbers of drug-DNA cross-links, causing equivalent lesions and biological effects. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Adenocarcinoma (Phase 4)
Adenocarcinoma, Bronchiolo-Alveolar (Phase 2)
Adenocarcinoma, Clear Cell (Phase 3)
Adenocarcinoma, Mucinous (Phase 3)
Adenocarcinoma of Lung (Phase 4)
Adrenocortical Carcinoma (Phase 1)
Anemia (Phase 3)
Angiogenesis Modulating Agents (Phase 2)
Anterior Cruciate Ligament Injuries (Phase 2)
Antineoplastic Agents (Phase 2)
Appendix (Phase 1)
Artificial Intelligence (Phase 2)
Ascites (Phase 2)
Astrocytoma (Phase 3)
Basal Cell Nevus Syndrome (Phase 2)
Beckwith-Wiedemann Syndrome (Phase 3)
Bile Duct Neoplasms (Phase 2)
Biliary Tract Neoplasms (Phase 3)
Bone Marrow Diseases (Phase 2)
Bone Neoplasms (Phase 1/Phase 2)
Brain Neoplasms (Phase 3)
Brain Stem Neoplasms (Phase 2)
BRCA1 Protein (Phase 2)
Breast (Phase 1/Phase 2)
Breast Diseases (Phase 2)
Breast Neoplasms (Phase 4)
Breast Neoplasms, Male (Phase 2)
Brenner Tumor (Phase 3)
Bronchial Diseases (Phase 3)
Bronchial Neoplasms (Phase 3)
Burkitt Lymphoma (Phase 2)
Carboplatin (Phase 3)
Carcinoma (Phase 4)
Carcinoma, Adenoid Cystic (Phase 2)
Carcinoma, Adenosquamous (Phase 3)
Carcinoma, Bronchogenic (Phase 3)
Carcinoma, Embryonal (Phase 2)
Carcinoma, Endometrioid (Phase 2)
Carcinoma, Hepatocellular (Phase 3)
Carcinoma, Intraductal, Noninfiltrating (Phase 2)
Carcinoma, Islet Cell (Phase 1)
Carcinoma, Large Cell (Phase 4)
Carcinoma, Merkel Cell (Phase 2)
Carcinoma, Mucoepidermoid (Phase 1)
Carcinoma, Neuroendocrine (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 4)
Carcinoma, Ovarian Epithelial (Phase 3)
Carcinoma, Pancreatic Ductal (Phase 1)
Carcinoma, Renal Cell (Phase 3)
Carcinoma, Small Cell (Phase 2)
Carcinoma, Squamous Cell (Phase 4)
Carcinoma, Transitional Cell (Phase 3)
Carcinoma, Verrucous (Phase 3)
Carcinosarcoma (Phase 2)
Castration (Phase 2)
Central Nervous System Neoplasms (Phase 3)
Chemoradiotherapy (Phase 3)
Chemotherapy, Adjuvant (Phase 3)
Chemotherapy, Cancer, Regional Perfusion (Phase 2)
Chest Wall Oscillation (Phase 2)
Child (Phase 2)
Cholangiocarcinoma (Phase 3)
Choriocarcinoma (Phase 3)
Choroid Plexus Neoplasms (Phase 3)
Circulating Tumor DNA (Phase 2)
Cisplatin (Phase 3)
Clonal Hematopoiesis (Phase 2)
Cognition Disorders (Phase 3)
Colonic Neoplasms (Phase 3)
Colorectal Neoplasms (Phase 3)
Colorectal Neoplasms, Hereditary Nonpolyposis (Early Phase 1)
Cytoreduction Surgical Procedures (Phase 2)
Deglutition Disorders (Phase 2)
Diffuse Intrinsic Pontine Glioma (Phase 2)
Digestive System Neoplasms (Phase 2)
DNA Mismatch Repair (Phase 1)
Drugs, Investigational (Phase 3)
Drug Therapy (Phase 2)
Drug Therapy, Combination (Phase 1/Phase 2)
Edema (Phase 2)
Endocrine System Diseases (Phase 2)
Endodermal Sinus Tumor (Phase 3)
Endometrial Neoplasms (Phase 3)
Ependymoma (Phase 3)
Epidermal Growth Factor (Phase 3)
Erythema (Phase 2)
Esophageal Neoplasms (Phase 3)
Esophageal Squamous Cell Carcinoma (Phase 3)
Fallopian Tube Neoplasms (Phase 3)
Fallopian Tubes (Phase 1)
Fatigue (Phase 3)
Gallbladder Neoplasms (Phase 3)
Ganglioneuroblastoma (Phase 3)
Gastrinoma (Phase 1)
Gastrointestinal Stromal Tumors (Phase 2)
General Surgery (Phase 2)
Genital Diseases, Female (Phase 3)
Genital Neoplasms, Female (Phase 3)
Geriatrics (Phase 2)
Germinoma (Phase 3)
Gestational Trophoblastic Disease (Phase 3)
Glioblastoma (Phase 3)
Glioma (Phase 3)
Gliosarcoma (Phase 2)
Glucagonoma (Phase 1)
Graft vs Host Disease (Phase 2)
Hamartoma (Phase 3)
Head and Neck Neoplasms (Phase 3)
Hemoptysis (Phase 2)
Hepatoblastoma (Phase 3)
HIV (Phase 2)
HIV Infections (Phase 2)
Hodgkin Disease (Phase 3)
Homologous Recombination (Phase 2)
Human papillomavirus 16 (Phase 2)
Hypertrophy (Phase 3)
Hypopharyngeal Neoplasms (Phase 3)
Immunotherapy (Phase 3)
Induction Chemotherapy (Phase 2)
Infections (Phase 1)
Inflammatory Breast Neoplasms (Phase 3)
Informed Consent (Phase 2)
Insulinoma (Phase 1)
Intestinal Neoplasms (Phase 2)
Intraocular Lymphoma (Phase 2)
Kidney Diseases (Phase 3)
Kidney Neoplasms (Phase 3)
Lapatinib (Phase 2)
Laryngeal Neoplasms (Phase 3)
Larynx (Phase 2)
Leiomyosarcoma (Phase 2)
Leukemia (Phase 2/Phase 3)
Leukemia, B-Cell (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 2)
Leukemia, Monocytic, Acute (Phase 2)
Leukemia, Myeloid, Acute (Phase 2)
Leukemia, Myeloid, Chronic-Phase (Phase 1)
Leukemia, Myelomonocytic, Acute (Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Leydig Cell Tumor (Phase 1)
Lip Neoplasms (Phase 2)
Liver Failure (Phase 1)
Liver Neoplasms (Phase 3)
Lung Diseases (Phase 3)
Lung Neoplasms (Phase 4)
Lymphadenopathy (Phase 1/Phase 2)
Lymph Nodes (Phase 2)
Lymphoma (Phase 3)
Lymphoma, B-Cell (Phase 2)
Lymphoma, B-Cell, Marginal Zone (Phase 2)
Lymphoma, Follicular (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 3)
Lymphoma, Large-Cell, Anaplastic (Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 3)
Lymphoma, T-Cell (Phase 2)
Lymphoma, T-Cell, Peripheral (Phase 2)
Lymphomatoid Granulomatosis (Phase 2)
Medulloblastoma (Phase 4)
Melanoma (Phase 3)
Mesothelioma (Phase 3)
Mesothelioma, Malignant (Phase 2)
Mixed Tumor, Mesodermal (Phase 2)
Mixed Tumor, Mullerian (Phase 2)
Mouth Neoplasms (Phase 3)
Mucositis (Phase 2)
Multiple Myeloma (Phase 2)
Musculoskeletal Diseases (Phase 2)
Mutation (Phase 3)
Mycosis Fungoides (Phase 1)
Myelodysplastic Syndromes (Phase 2/Phase 3)
Myeloproliferative Disorders (Phase 3)
Nasal Cavity (Phase 2)
Nasopharyngeal Carcinoma (Phase 3)
Nasopharyngeal Neoplasms (Phase 2)
Nausea (Phase 2)
Neoadjuvant Therapy (Phase 2)
Neoplasm Metastasis (Phase 3)
Neoplasm, Residual (Phase 2)
Neoplasms (Phase 4)
Neoplasms by Histologic Type (Phase 3)
Neoplasms by Site (Phase 3)
Neoplasms, Germ Cell and Embryonal (Phase 4)
Neoplasms, Glandular and Epithelial (Phase 2)
Neoplasms, Nerve Tissue (Phase 3)
Neoplasms, Second Primary (Phase 4)
Neoplasms, Squamous Cell (Phase 1/Phase 2)
Neoplasms, Unknown Primary (Phase 3)
Neuroblastoma (Phase 3)
Neuroectodermal Tumors (Phase 3)
Neuroectodermal Tumors, Primitive (Phase 2)
Neuroendocrine Tumors (Phase 4)
Neurofibromatosis 1 (Phase 3)
Neurotoxicity Syndromes (Phase 3)
Neutropenia (Phase 1)
Obesity (Phase 3)
Oligodendroglioma (Phase 2)
Oncogene Proteins (Phase 2)
Oncogenes (Phase 2)
Optic Nerve Glioma (Phase 1/Phase 2)
Oropharyngeal Neoplasms (Phase 3)
Osteosarcoma (Phase 2)
Ototoxicity (Phase 3)
Ovarian Diseases (Phase 3)
Paclitaxel (Phase 1)
Pain (Phase 3)
Pancreatic Neoplasms (Phase 2)
Papillomaviridae (Phase 2)
Papillomavirus Infections (Phase 2)
Paranasal Sinuses (Phase 2)
Pelvic Neoplasms (Phase 3)
Peripheral Nerve Injuries (Phase 3)
Peritoneal Neoplasms (Phase 3)
Pharmacokinetics (Phase 1)
Pharyngeal Neoplasms (Phase 2)
Platinum Compounds (Phase 3)
Pleural Effusion, Malignant (Phase 2)
Polycythemia Vera (Phase 2)
Postoperative Complications (Phase 2)
Precancerous Conditions (Phase 2)
Primary Myelofibrosis (Phase 2)
Progression-Free Survival (Phase 3)
Prostatic Neoplasms (Phase 3)
Prosthesis Failure (Phase 2)
Protein Kinase Inhibitors (Phase 1/Phase 2)
Pseudomyxoma Peritonei (Phase 1)
Quality of Life (Phase 3)
Radiation Oncology (Phase 2)
Radiosurgery (Phase 2)
Radiotherapy (Phase 3)
Rectal Neoplasms (Phase 3)
Recurrence (Phase 1/Phase 2)
Renal Insufficiency (Phase 1)
Respiratory Tract Diseases (Phase 3)
Respiratory Tract Neoplasms (Phase 3)
Retinal Neoplasms (Phase 3)
Retinoblastoma (Phase 4)
Rhabdoid Tumor (Phase 3)
Rhabdomyosarcoma (Phase 3)
Risk Factors (Phase 2)
Salivary Gland Neoplasms (Phase 3)
Sarcoma (Phase 3)
Sarcoma, Clear Cell (Phase 2)
Sarcoma, Ewing (Phase 2)
Seminoma (Phase 3)
Sepsis (Phase 2)
Sezary Syndrome (Phase 2)
Skin Diseases (Phase 2)
Skin Neoplasms (Phase 3)
Small Cell Lung Carcinoma (Phase 3)
Somatostatinoma (Phase 1)
Squamous Cell Carcinoma of Head and Neck (Phase 4)
Stomach Neoplasms (Phase 3)
Teratoma (Phase 3)
Testicular Neoplasms (Phase 3)
Therapeutics (Phase 2)
Thoracic Neoplasms (Phase 3)
Thrombocythemia, Essential (Phase 2)
Thrombocytopenia (Phase 2)
Thymoma (Phase 2)
Thyroid Carcinoma, Anaplastic (Phase 3)
Thyroid Neoplasms (Phase 1)
Tissue Adhesions (Phase 2)
Tongue Neoplasms (Phase 3)
Triple Negative Breast Neoplasms (Phase 3)
Tumor Virus Infections (Phase 1)
Ureteral Neoplasms (Phase 2)
Urethral Neoplasms (Phase 3)
Urinary Bladder Neoplasms (Phase 3)
Urogenital Neoplasms (Phase 2)
Urologic Neoplasms (Phase 2)
Uterine Cervical Diseases (Phase 2)
Uterine Cervical Neoplasms (Phase 3)
Uterine Diseases (Phase 2)
Uterine Neoplasms (Phase 3)
Vaginal Neoplasms (Phase 1)
Venous Thromboembolism (Phase 1)
Vipoma (Phase 1)
Vomiting (Phase 2)
Vulvar Neoplasms (Phase 1)
Waldenstrom Macroglobulinemia (Phase 2)
Wilms Tumor (Phase 3)
Xerostomia (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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