Active Ingredient History

  • Now
Quinacrine was initially developed as an anti-malarial drug marketed under the name Atabrine. Also it was approved for the teratment of ascites, however it was wothdrawn for both indication in 1995 and 2003, respectively. The drug is also used for the treatment of giardiasis, lupus, rheumatoid arthritis, refractory pulmonary effusion and pneumothorax, induce female sterilization etc. Proposed mechanisms of action include DNA intercalation interference with RNA transcription and translation, inhibition of succinate oxidation interference with electron transport, inhibition of cholinesterase, and inhibitor of phospholipase.   NCATS

More Chemistry
2-methoxy-6-chloro-9-diethylaminopentylaminoacridine | 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine | 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine | acrinamine | acriquine | atabrine | atebrine | gnf-pf-5448 | mepacrine | n4-(6-chloro-2-methoxy-9-acridinyl)-n1,n1-diethyl-1,4-pentanediamine | quinacrin | quinacrine | quinacrine dihydrochloride | quinacrine dihydrochloride hydrate | quinacrine hcl | quinacrine hydrochloride


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