Active Ingredient History
Prochlorperazine is a piperazine phenothiazine antipsychotic which block postsynaptic mesolimbic dopaminergic receptors in the brain and has antiemetic effects by its antagonist actions in the D2 dopamine receptors in the chemoreceptor trigger zone. It also exhibits alpha-adrenergic blocking effect on α1 receptros and may depress the release of hypothalamic and hypophyseal hormones. Prochlorperazine is used for the control of severe nausea and vomiting, for the treatment of schizophrenia. Prochlorperazine is effective for the short-term treatment of generalized non-psychotic anxiety. Prochlorperazine may be an effective treatment of acute headaches and refractory chronic daily headache. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Anxiety (approved 1959)
Nausea (approved 1959)
Schizophrenia (approved 1959)
Vomiting (approved 1959)
Acute Lung Injury (Phase 1/Phase 2)
Breast Neoplasms (Phase 3)
Cardiotoxicity (Phase 1)
COVID-19 (Phase 1/Phase 2)
Dengue ()
Emergency Service, Hospital (Phase 2)
Epilepsy (Phase 2)
Facial Neuralgia (Phase 3)
Genital Neoplasms, Female (Phase 3)
Headache (Phase 4)
Headache Disorders, Primary (Phase 2)
Healthy Volunteers (Phase 1)
Laparoscopy (Phase 4)
Migraine Disorders (Phase 4)
Migraine with Aura (Phase 2)
Multiple Myeloma (Early Phase 1)
Nausea (Phase 4)
Neoplasms (Phase 3)
Pain Management (Phase 2)
Pneumonia (Phase 1/Phase 2)
Respiratory Distress Syndrome (Phase 1/Phase 2)
Rhytidoplasty (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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