Active Ingredient History

  • Now
Donepezil, marketed under the trade name Aricept, is a medication used in the palliative treatment of Alzheimer's disease. Aricept is indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mild to moderate Alzheimer’s Disease, as well as in patients with severe Alzheimer’s Disease. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.   NCATS

  • SMILES: COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
  • Mol. Mass: 379.5
  • ALogP: 4.36
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0332 - $16.6157


$0.2786 - $0.5278
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride | aricept | aricept evess | aricept odt | bnag | domepezil | donepezil | donepezil hcl | donepezil hydrochloride | donepezil hydrochloride monohydrate | donepezilium oxalate | donepezilium oxalate trihydrate | donepezilo | donepezil oxalate | donepezilum | donezepil | donezpil | donezpil hcl | donezpil hydrochloride | donzepezil | e2020 | e 2020 | e-2020 | eranz | memantine hydrochloride / donepezil hydrochloride


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