Active Ingredient History
Atorvastatin calcium (LIPITOR®) is a pyrrole and heptanoic acid derivative, a synthetic lipid-lowering agent. Atorvastatin is a selective, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. Atorvastatin is used to reduce serum levels of LDL(low-density lipoprotein)-cholesterol; apolipoprotein B; and triglycerides and to increase serum levels of HDL(high-density lipoprotein)-cholesterol in the treatment of hyperlipidemias and prevention of cardiovascular disease in patients with multiple risk factors. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Cardiovascular Diseases (approved 1996)
Hyperlipidemias (approved 1996)
Acne Vulgaris (Phase 4)
Acute Chest Syndrome (Phase 3)
Acute Coronary Syndrome (Phase 4)
Acute Kidney Injury (Phase 4)
Aged (Phase 4)
AIDS Dementia Complex (Phase 4)
Alzheimer Disease (Phase 3)
Anemia, Sickle Cell (Phase 2)
Angina Pectoris (Phase 4)
Angina Pectoris, Variant (Phase 4)
Angina, Unstable (Phase 4)
Angioplasty (Phase 4)
Angioplasty, Balloon, Coronary (Phase 2)
Anterior Wall Myocardial Infarction (Phase 4)
Aortic Aneurysm, Abdominal (Phase 4)
Aortic Coarctation (Phase 4)
Aortic Diseases (Phase 3)
Aortic Valve Stenosis (Phase 4)
Arrhythmias, Cardiac (Phase 4)
Arterial Occlusive Diseases (Phase 2/Phase 3)
Arteriosclerosis (Phase 4)
Arthritis, Rheumatoid (Phase 4)
Asthma (Phase 2/Phase 3)
Atherosclerosis (Phase 4)
Atorvastatin (Phase 4)
Atrial Fibrillation (Phase 4)
Bicuspid Aortic Valve Disease (Phase 3)
Blood Circulation (Phase 1)
Blood Platelet Disorders (Phase 2)
Blood Pressure (Phase 4)
Bone Marrow Cells (Phase 2)
Brain Injuries, Traumatic (Phase 2)
Breast Neoplasms (Phase 3)
Bronchiectasis (Phase 4)
Calcinosis (Phase 4)
Carcinoma, Hepatocellular (Phase 4)
Carcinoma, Renal Cell (Phase 2)
Cardiomyopathies (Phase 4)
Cardiomyopathy, Hypertrophic (Phase 3)
Cardiotoxicity (Phase 2)
Cardiovascular Diseases (Phase 4)
Carotid Artery Diseases (Phase 4)
Carotid Stenosis (Phase 4)
Cerebral Hemorrhage (Phase 2/Phase 3)
Cerebral Infarction (Phase 4)
Chagas Disease (Phase 2)
Cholesterol, HDL (Phase 4)
Cholesterol, LDL (Phase 4)
Chromosome Aberrations (Phase 2)
Chronic Periodontitis (Phase 2/Phase 3)
Cognition (Phase 4)
Cognition Disorders (Phase 3)
Cognitive Dysfunction (Phase 4)
Colitis, Ulcerative (Phase 2)
Colonic Neoplasms (Phase 2)
Colorectal Neoplasms (Phase 2)
Colorectal Neoplasms, Hereditary Nonpolyposis (Early Phase 1)
Constriction, Pathologic (Phase 1/Phase 2)
Coronary Aneurysm (Phase 2)
Coronary Artery Bypass (Phase 4)
Coronary Disease (Phase 4)
COVID-19 (Phase 3)
Crohn Disease (Phase 2)
Dementia (Phase 4)
Diabetes Insipidus (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Disability Evaluation (Phase 4)
Drug Interactions (Phase 1)
Dual Anti-Platelet Therapy (Phase 2)
Dyslipidemias (Phase 4)
Elective Surgical Procedures (Phase 4)
Endometrial Neoplasms (Early Phase 1)
Endometriosis (Phase 1)
Endothelial Cells (Phase 4)
Endothelium (Phase 4)
Epilepsy (Phase 1)
Erectile Dysfunction (Phase 2)
Essential Hypertension (Phase 4)
Fatty Liver (Phase 4)
Fibrosis (Phase 2)
Fistula (Phase 2)
Foot Ulcer (Phase 2)
Gene Expression (Phase 4)
General Surgery (Phase 4)
Glioblastoma (Phase 2)
Glomerulonephritis, IGA (Phase 2)
Glomerulosclerosis, Focal Segmental (Phase 2)
Glucose Metabolism Disorders (Phase 4)
Graft vs Host Disease (Phase 2)
Graves Ophthalmopathy (Phase 4)
Head and Neck Neoplasms (Phase 3)
Healthy Volunteers (Phase 4)
Hearing Loss (Phase 3)
Heart (Phase 4)
Heart Disease Risk Factors (Phase 3)
Heart Diseases (Phase 4)
Heart Failure, Systolic (Phase 4)
Heart Valve Diseases (Phase 3)
Helicobacter pylori (Phase 4)
Hemangioma, Cavernous, Central Nervous System (Phase 1/Phase 2)
Hematoma, Subdural, Chronic (Phase 3)
Hemorrhagic Fever, Ebola (Phase 1/Phase 2)
Hemostasis (Phase 4)
Hepatitis B (Phase 4)
Hepatitis C (Phase 4)
Hip Fractures (Phase 2)
HIV (Phase 3)
HIV Infections (Phase 4)
HIV Seronegativity (Phase 1)
Hodgkin Disease (Phase 2)
Homozygous Familial Hypercholesterolemia (Phase 3)
Hyperglycemia (Phase 4)
Hyperlipidemia, Familial Combined (Phase 3)
Hyperlipoproteinemia Type III (Phase 3)
Hyperlipoproteinemia Type IV (Phase 3)
Hyperparathyroidism, Secondary (Phase 4)
Hyperplasia (Phase 1)
Hypertension ()
Hypertension, Pulmonary (Phase 2)
Hypertension, Renovascular (Phase 3)
Hypertriglyceridemia (Phase 4)
Hypertrophy, Left Ventricular (Phase 3)
Immune Reconstitution Inflammatory Syndrome (Phase 2/Phase 3)
Immunosuppression Therapy (Phase 4)
Independent Living (Phase 4)
Infertility, Male (Phase 1)
Inflammation (Phase 4)
Inflammatory Breast Neoplasms (Phase 2)
Influenza, Human (Phase 2)
Insulin Resistance (Phase 4)
Intermittent Claudication (Phase 2/Phase 3)
Intracranial Aneurysm (Phase 2)
Intracranial Arteriosclerosis (Phase 4)
Ischemia (Phase 4)
Ischemic Attack, Transient (Phase 3)
Ischemic Stroke (Phase 4)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 1)
Kidney Neoplasms (Phase 2)
Leukemia (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Myeloid, Acute (Phase 3)
Leukemia, Prolymphocytic (Phase 2)
Lipid Metabolism Disorders (Phase 4)
Lipodystrophy (Phase 1)
Liver Cirrhosis (Phase 4)
Liver Cirrhosis, Biliary (Phase 3)
Liver Diseases (Phase 2)
Lung (Phase 4)
Lupus Erythematosus, Systemic (Phase 4)
Lymphoma (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 2)
Macular Degeneration (Phase 2)
Magnetic Resonance Imaging (Phase 4)
Medicine, Chinese Traditional (Phase 4)
Metabolic Syndrome (Phase 4)
Metabolism (Phase 4)
Mitochondrial Diseases (Phase 4)
Mood Disorders (Phase 4)
Mucocutaneous Lymph Node Syndrome (Phase 2)
Multiple Myeloma (Phase 2)
Multiple Sclerosis (Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 2)
Muscular Diseases (Phase 4)
Myalgia (Phase 2)
Myelodysplastic Syndromes (Phase 3)
Myeloproliferative Disorders (Phase 2)
Myocardial Ischemia (Phase 4)
Myocardial Stunning (Phase 4)
Myocardium (Phase 3)
Nasopharyngeal Carcinoma (Phase 2)
Neoplasm Metastasis (Phase 1)
Neoplasms (Phase 3)
Neuropsychology (Phase 4)
Non-alcoholic Fatty Liver Disease (Phase 2)
Non-ST Elevated Myocardial Infarction (Phase 3)
Obesity (Phase 4)
Osteoarthritis (Phase 4)
Osteoporosis (Phase 4)
Oxidative Stress (Phase 4)
Percutaneous Coronary Intervention (Phase 4)
Periodontal Diseases (Phase 4)
Periodontitis (Phase 2)
Peripheral Arterial Disease (Phase 4)
Peripheral Vascular Diseases (Phase 4)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 4)
Pneumonia, Ventilator-Associated (Early Phase 1)
Polycystic Ovary Syndrome (Phase 2)
Postmenopause (Phase 2)
Postoperative Complications (Phase 4)
Precancerous Conditions (Phase 2)
Prediabetic State (Phase 4)
Pre-Eclampsia (Phase 3)
Prostatic Hyperplasia (Phase 4)
Prostatic Neoplasms (Phase 3)
Psoriasis (Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Purpura, Thrombocytopenic (Phase 4)
Purpura, Thrombocytopenic, Idiopathic (Phase 4)
Quality of Life (Phase 4)
Radiation Oncology (Phase 2)
Rectal Neoplasms (Phase 2)
Renal Artery Obstruction (Phase 3)
Renal Insufficiency (Phase 3)
Renal Insufficiency, Chronic (Phase 4)
Reperfusion Injury (Phase 4)
Retinal Drusen (Phase 4)
Retinal Vein Occlusion (Phase 3)
Retroperitoneal Fibrosis (Phase 4)
Sarcoidosis, Pulmonary (Phase 2)
SARS-CoV-2 (Phase 2/Phase 3)
Scleroderma, Systemic (Phase 2)
Sepsis (Phase 2)
Sleep Apnea, Obstructive (Phase 2)
Sleep Wake Disorders (Phase 1)
Smoking (Phase 4)
Spastic Paraplegia, Hereditary (Phase 2)
Sprains and Strains (Phase 4)
ST Elevation Myocardial Infarction (Phase 4)
Stem Cell Transplantation (Phase 2)
Stress Disorders, Post-Traumatic (Phase 2)
Stroke ()
Thoracic Surgery (Phase 4)
Thrombosis (Phase 4)
Triple Negative Breast Neoplasms (Phase 2)
Tuberculosis (Phase 2/Phase 3)
Tuberculosis, Pulmonary (Phase 2/Phase 3)
Ultrasonography, Interventional (Phase 4)
Vaccination (Phase 4)
Vascular Calcification (Phase 3)
Vascular Diseases (Phase 4)
Vascular Grafting (Phase 3)
Vascular Stiffness (Phase 4)
Vascular Surgical Procedures (Phase 4)
Venous Thromboembolism (Phase 2)
Vitiligo (Phase 2)
Waldenstrom Macroglobulinemia (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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